Among the neurotransmitter abnormalities that have been investigated in Alzheimer's
disease (AD), deficits in the cholinergic system have been the most intensively studied …

A modular organization of bands enriched in high concentrations of D2 receptors are
observed throughout the rostral to caudal aspects of the temporal cortex of the normal …

Objective Dopamine D2‐like receptors–mainly dopamine D2 receptors (D2R) and
dopamine D3 receptors (D3R)–are believed to be greatly involved in the pathology of …

The expression of the human dopamine D1 receptor was examined by reverse transcription
polymerase chain reaction (RT-PCR) and radioligand binding using [3H]-SCH23390 in post …

Post mortem studies have revealed a loss of dopamine D2 receptors in the temporal lobes in
Alzheimer's disease (AD). Moreover, the role of hippocampal D2 receptors on memory …

Background Lewy bodies (LB) are present in at least 20% to 30% of persons with Alzheimer
disease (AD) and contribute to the risk of psychosis and to excess cognitive burden …

The anatomy of the hippocampus, including the organization of its intrinsic neural circuits
and afferents, is organized along a rostrocaudal axis. Dopamine D2 receptors are …

A significant proportion of patients with Alzheimer's disease (AD) exhibit extrapyramidal
features that are referred to as parkinsonism (AD/Park) to distinguish the clinical and …

Previous studies have documented a highly compartmentalized and laminar organization of
dopamine D2 receptors in human hippocampus, entorhinal and perirhinal cortices. These …

Background Dopamine receptors interact with other receptors to form heterooligomers. One
such complex, the D1-D2 heteromer, demonstrated in cultured striatal neurons and rat …