The endogenous opioid system: a common substrate in drug addiction
Drug addiction is a chronic brain disorder leading to complex adaptive changes within the
brain reward circuits that involve several neurotransmitters. One of the neurochemical …
brain reward circuits that involve several neurotransmitters. One of the neurochemical …
The endogenous opioid system in human alcoholics: molecular adaptations in brain areas involved in cognitive control of addiction
I Bazov, O Kononenko, H Watanabe, V Kuntić… - Addiction …, 2013 - Wiley Online Library
The endogenous opioid system (EOS) plays a critical role in addictive processes. Molecular
dysregulations in this system may be specific for different stages of addiction cycle and …
dysregulations in this system may be specific for different stages of addiction cycle and …
[HTML][HTML] Reward processing by the opioid system in the brain
J Le Merrer, JAJ Becker, K Befort… - Physiological …, 2009 - journals.physiology.org
The opioid system consists of three receptors, mu, delta, and kappa, which are activated by
endogenous opioid peptides processed from three protein precursors, proopiomelanocortin …
endogenous opioid peptides processed from three protein precursors, proopiomelanocortin …
Modulation of alcohol and nicotine responses through the endogenous opioid system
E Drews, A Zimmer - Progress in neurobiology, 2010 - Elsevier
It has been estimated that more than 80% of alcoholics are also nicotine dependent and
that, vice versa, the rate of alcoholism is substantially increased by a factor of 4–10 in the …
that, vice versa, the rate of alcoholism is substantially increased by a factor of 4–10 in the …
Drug dependence and the endogenous opioid system
MAFM Gerrits, HBM Lesscher, JM van Ree - European …, 2003 - Elsevier
The discovery of endogenous opioids has markedly influenced the research on the biology
of drug dependence. Evidence has been presented that these brain substances are self …
of drug dependence. Evidence has been presented that these brain substances are self …
Endogenous opioids and addiction to alcohol and other drugs of abuse
C Gianoulakis - Current topics in medicinal chemistry, 2009 - ingentaconnect.com
There is significant experimental evidence implicating the endogenous opioid system
(opioid peptides and opioid receptors) with the processes of reward and reinforcement …
(opioid peptides and opioid receptors) with the processes of reward and reinforcement …
Endogenous opioids and addiction to alcohol and other drugs of abuse
C Gianoulakis - Current topics in medicinal chemistry, 2004 - ingentaconnect.com
There is significant experimental evidence implicating the endogenous opioid system
(opioid peptides and opioid receptors) with the processes of reward and reinforcement …
(opioid peptides and opioid receptors) with the processes of reward and reinforcement …
[PDF][PDF] Endogenous opioids: overview and current issues
H Akil, C Owens, H Gutstein, L Taylor, E Curran… - Drug Alcohol …, 1998 - academia.edu
It is now well established that opiate drugs, such as heroin and morphine exert their primary
effects by mimicking naturally occurring substances, termed the opioid peptides or …
effects by mimicking naturally occurring substances, termed the opioid peptides or …
Endogenous opioids at the intersection of opioid addiction, pain, and depression: the search for a precision medicine approach
Opioid addiction and overdose are at record levels in the United States. This is driven, in
part, by their widespread prescription for the treatment of pain, which also increased …
part, by their widespread prescription for the treatment of pain, which also increased …
The neurobiology of addiction
R Maldonado - Addiction Mechanisms, Phenomenology and …, 2003 - Springer
Drug addiction includes complex neurobiological and behavioural processes. Acute
reinforcing effects of drugs of abuse are responsible for the initiation of drug addiction …
reinforcing effects of drugs of abuse are responsible for the initiation of drug addiction …