[HTML][HTML] Carpachromene ameliorates insulin resistance in HepG2 cells via modulating IR/IRS1/PI3k/Akt/GSK3/FoxO1 pathway

R Alaaeldin, IAM Abdel-Rahman, HA Hassan… - Molecules, 2021 - mdpi.com
Insulin resistance contributes to several disorders including type 2 diabetes and
cardiovascular diseases. Carpachromene is a natural active compound that inhibits α …

Chrysin improves glucose and lipid metabolism disorders by regulating the AMPK/PI3K/AKT signaling pathway in insulin-resistant HepG2 cells and HFD/STZ-induced …

YJ Zhou, N Xu, XC Zhang, YY Zhu… - Journal of Agricultural …, 2021 - ACS Publications
Natural products with minor side effects have been reported to be an effective adjuvant
therapy for glucose and lipid metabolism disorders. Chrysin, a flavone, has a wide range of …

[HTML][HTML] Aspalathin-enriched green rooibos extract reduces hepatic insulin resistance by modulating PI3K/AKT and AMPK pathways

SE Mazibuko-Mbeje, PV Dludla, C Roux… - International journal of …, 2019 - mdpi.com
We previously demonstrated that an aspalathin-enriched green rooibos extract (GRE)
reversed palmitate-induced insulin resistance in C2C12 skeletal muscle and 3T3-L1 fat cells …

[HTML][HTML] Edgeworthia gardneri (Wall.) Meisn. Water Extract Ameliorates Palmitate Induced Insulin Resistance by Regulating IRS1/GSK3β/FoxO1 Signaling Pathway in …

Y Zhang, LS Yan, Y Ding, BCY Cheng, G Luo… - Frontiers in …, 2020 - frontiersin.org
The flower of Edgeworthia gardneri (Wall.) Meisn is commonly used in beverage products in
Tibet and has potential health benefits for diabetes. However, the mechanisms underlying …

Poncirin, an orally active flavonoid exerts antidiabetic complications and improves glucose uptake activating PI3K/Akt signaling pathway in insulin resistant C2C12 …

MY Ali, S Zaib, MM Rahman, S Jannat, J Iqbal… - Bioorganic …, 2020 - Elsevier
Poncirin, a natural flavanone glycoside present abundantly in many citrus fruits, contains an
extensive range of biological activities. However, the antidiabetic mechanism of poncirin is …

[HTML][HTML] Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats

SJ Jiang, H Dong, JB Li, LJ Xu, X Zou… - World Journal of …, 2015 - ncbi.nlm.nih.gov
AIM: To investigate the molecular mechanisms of berberine inhibition of hepatic
gluconeogenesis in a diabetic rat model. METHODS: The 40 rats were randomly divided into …

[HTML][HTML] Polyphenol from Rosa roxburghii Tratt Fruit Ameliorates the Symptoms of Diabetes by Activating the P13K/AKT Insulin Pathway in db/db Mice

C Chen, S Tan, T Ren, H Wang, X Dai, H Wang - Foods, 2022 - mdpi.com
About 4% of the world's population has type 2 diabetes mellitus (T2DM), and the available
hypoglycemic drugs for treating diabetes have some side effects. Therefore, research on the …

Fucoxanthin ameliorates hyperglycemia, hyperlipidemia and insulin resistance in diabetic mice partially through IRS-1/PI3K/Akt and AMPK pathways

Y Zhang, W Xu, X Huang, Y Zhao, Q Ren, Z Hong… - Journal of functional …, 2018 - Elsevier
Fucoxanthin has potential anti-diabetic activities, but its precise effects and underlying
mechanisms remain unclear. In this study, C57BL/KsJ-db/db mice were fed diets containing …

Galangin and pinocembrin from propolis ameliorate insulin resistance in HepG2 cells via regulating Akt/mTOR signaling

Y Liu, X Liang, G Zhang, L Kong… - Evidence‐Based …, 2018 - Wiley Online Library
Insulin resistance has a critical role in type 2 diabetes. The aim of this study was to
investigate the effect of pinobanksin, galangin, chrysin, and pinocembrin from propolis on …

Crocin Improves Insulin Sensitivity and Ameliorates Adiposity by Regulating AMPK‐CDK5‐PPARγ Signaling

K Fang, M Gu - BioMed Research International, 2020 - Wiley Online Library
Crocin is a carotenoid compound which possesses multiple biological activities. Our and
other laboratory's previous findings show that crocin alleviates obesity and type 2 diabetes …