[HTML][HTML] Loss of the Spinocerebellar Ataxia type 3 disease protein ATXN3 alters transcription of multiple signal transduction pathways
Spinocerebellar ataxia type 3 (SCA3) is a dominantly inherited neurodegenerative disorder
caused by a polyglutamine-encoding CAG repeat expansion in the ATXN3 gene which …
caused by a polyglutamine-encoding CAG repeat expansion in the ATXN3 gene which …
Inactivation of the mouse Atxn3 (ataxin-3) gene increases protein ubiquitination
I Schmitt, M Linden, H Khazneh, BO Evert… - Biochemical and …, 2007 - Elsevier
Spinocerebellar ataxia type 3 is a neurodegenerative disease caused by expansion of a
polyglutamine domain in the protein ataxin-3 (ATXN3). Physiological functions of ATXN3 …
polyglutamine domain in the protein ataxin-3 (ATXN3). Physiological functions of ATXN3 …
[HTML][HTML] Partial loss of ataxin-1 function contributes to transcriptional dysregulation in spinocerebellar ataxia type 1 pathogenesis
Spinocerebellar ataxia type 1 (SCA1) is a dominantly inherited neurodegenerative disease
caused by expansion of a CAG repeat that encodes a polyglutamine tract in ATAXIN1 …
caused by expansion of a CAG repeat that encodes a polyglutamine tract in ATAXIN1 …
Comparison of spinocerebellar ataxia type 3 mouse models identifies early gain-of-function, cell-autonomous transcriptional changes in oligodendrocytes
Abstract Spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disorder caused by a
polyglutamine-encoding CAG repeat expansion in the ATXN3 gene. This expansion leads to …
polyglutamine-encoding CAG repeat expansion in the ATXN3 gene. This expansion leads to …
Spinocerebellar ataxia type 1: Molecular mechanisms of neurodegeneration and preclinical studies
JM Pérez Ortiz, HT Orr - Polyglutamine Disorders, 2018 - Springer
Abstract Spinocerebellar ataxia type 1 (SCA1) is an adult-onset, inherited disease that leads
to degeneration of Purkinje cells of the cerebellum and culminates in death 10–30 years …
to degeneration of Purkinje cells of the cerebellum and culminates in death 10–30 years …
[HTML][HTML] Mutant ataxin1 disrupts cerebellar development in spinocerebellar ataxia type 1
Spinocerebellar ataxia type 1 (SCA1) is an adult-onset neurodegenerative disease caused
by a polyglutamine expansion in the protein ATXN1, which is involved in transcriptional …
by a polyglutamine expansion in the protein ATXN1, which is involved in transcriptional …
Impaired oligodendrocyte maturation is an early feature in SCA3 disease pathogenesis
Spinocerebellar ataxia Type 3 (SCA3), the most common dominantly inherited ataxia, is a
polyglutamine neurodegenerative disease for which there is no disease-modifying therapy …
polyglutamine neurodegenerative disease for which there is no disease-modifying therapy …
[HTML][HTML] Ubiquitin-binding site 1 of pathogenic ataxin-3 regulates its toxicity in Drosophila models of Spinocerebellar Ataxia Type 3
Spinocerebellar Ataxia Type 3 (SCA3) is a member of the family of polyglutamine (polyQ)
diseases that are caused by anomalous CAG triplet repeat expansions in several genes …
diseases that are caused by anomalous CAG triplet repeat expansions in several genes …
Phosphorylation of ATXN1 at Ser776 in the cerebellum
ND Jorgensen, JM Andresen, S Lagalwar… - Journal of …, 2009 - Wiley Online Library
Abstract Spinocerebellar ataxia type 1 (SCA1) is one of nine inherited neurodegenerative
disorders caused by a mutant protein with an expanded polyglutamine tract …
disorders caused by a mutant protein with an expanded polyglutamine tract …
Gene co-expression network analysis for identifying modules and functionally enriched pathways in SCA2
LT Pflieger, W Dansithong, S Paul… - Human molecular …, 2017 - academic.oup.com
Abstract Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant neurodegenerative
disease caused by CAG repeat expansion in the ATXN2 gene. The repeat resides in an …
disease caused by CAG repeat expansion in the ATXN2 gene. The repeat resides in an …