Aspalathin from rooibos (Aspalathus linearis): a bioactive C-glucosyl dihydrochalcone with potential to target the metabolic syndrome

R Johnson, D de Beer, PV Dludla, D Ferreira… - Planta …, 2018 - thieme-connect.com
Aspalathin is a C-glucosyl dihydrochalcone that is abundantly present in Aspalathus
linearis. This endemic South African plant, belonging to the Cape Floristic region, is normally …

New insights into the efficacy of aspalathin and other related phytochemicals in type 2 diabetes—A review

CJF Muller, E Joubert, N Chellan, Y Miura… - International Journal of …, 2021 - mdpi.com
In the pursuit of bioactive phytochemicals as a therapeutic strategy to manage metabolic risk
factors for type 2 diabetes (T2D), aspalathin, C-glucosyl dihydrochalcone from rooibos …

In Vitro Hepatic Biotransformation of Aspalathin and Nothofagin, Dihydrochalcones of Rooibos (Aspalathus linearis), and Assessment of Metabolite Antioxidant …

JD Van Der Merwe, E Joubert, M Manley… - Journal of agricultural …, 2010 - ACS Publications
Aspalathin (2′, 3, 4, 4′, 6′-pentahydroxy-3′-C-β-d-glucopyranosyldihydrochalcone) is
the major flavonoid present in the South African herbal tea rooibos. In vitro metabolism of …

Acute assessment of an aspalathin-enriched green rooibos (Aspalathus linearis) extract with hypoglycemic potential

CJF Muller, E Joubert, D De Beer, M Sanderson… - Phytomedicine, 2012 - Elsevier
Rooibos, an endemic South African plant, known for its use as herbal tea, has potential as
an antidiabetic herbal product, following recent demonstration of the glucose lowering effect …

Inhibitory Interactions of Aspalathus linearis (Rooibos) Extracts and Compounds, Aspalathin and Z-2-(β-d-Glucopyranosyloxy)-3-phenylpropenoic Acid, on …

O Patel, C Muller, E Joubert, J Louw, B Rosenkranz… - Molecules, 2016 - mdpi.com
Rooibos extract, due to its glucose and lipid lowering effects, has potential as a nutraceutical
for improvement of metabolic dysfunction. Potential herb-drug interactions as a result of the …

Aspalathin, a flavonoid in Aspalathus linearis (rooibos), is absorbed by pig intestine as a C-glycoside

S Kreuz, E Joubert, KH Waldmann, W Ternes - Nutrition Research, 2008 - Elsevier
Aspalathin, a dihydrochalcone and C-glycoside, is the most abundant flavonoid in rooibos
(Aspalathus linearis), which is well known as an herbal tea in many countries. Aspalathin …

[HTML][HTML] Rooibos (Aspalathus linearis) beyond the farm gate: From herbal tea to potential phytopharmaceutical

E Joubert, D de Beer - South African Journal of Botany, 2011 - Elsevier
Aspalathus linearis (Burm. f.) Dahlg.(Fabaceae, Tribe Crotalarieae), an endemic South
African fynbos species, is cultivated to produce the well-known herbal tea, rooibos. It is …

Hypoglycemic effect of aspalathin, a rooibos tea component from Aspalathus linearis, in type 2 diabetic model db/db mice

A Kawano, H Nakamura, S Hata, M Minakawa, Y Miura… - Phytomedicine, 2009 - Elsevier
Effects of aspalathin, a green rooibos tea component, on glucose metabolism were studied
in vitro and in vivo. We first examined the effect of aspalathin on glucose uptake by cultured …

Aspalathin, a C-glucosyldihydrochalcone from rooibos improves the hypoglycemic potential of metformin in type 2 diabetic (db/db) mice

PV Dludla, KB Gabuza, CJF Muller, E Joubert, J Louw… - 2018 - scholar.sun.ac.za
Metformin is the first line therapy of type 2 diabetics, but continued reduction of their life
expectancy warrants further investigation into alternative treatment strategies. This study …

Anti‐diabetic and Anti‐hyperlipidemic Effects and Safety of Salacia reticulata and Related Species

SJ Stohs, S Ray - Phytotherapy Research, 2015 - Wiley Online Library
Extracts of Salacia reticulata Wight (Hypocrataceae) roots, stems, and leaves have been
used in Asia for hundreds of years for the folkloric treatment of diabetes and other health …