Several minor tobacco alkaloids have been found to exhibit properties pharmacologically
relevant to the addictive profile of tobacco; however, little is known of their effects on a …

Tobacco use is associated with lethal diseases in an estimated 440,000 persons in the
United States each year (Centers for Disease Control and Prevention, 2005). Successful …

Tobacco smoking has been shown to be quite addictive in people. However, nicotine itself is
a weak reinforcer compared to other commonly abused drugs, leading speculation that other …

Background While nicotine is the primary addictive compound in tobacco, other tobacco
constituents including minor alkaloids (eg, nornicotine, anabasine) may also contribute to …

Rationale: Chronic nicotine administration results in dynamic changes in neuronal function,
expressed as behavioral sensitization in animals and addiction in smokers. Objectives: The …

Rationale: Nicotine is a tobacco alkaloid known to be important in the acquisition and
maintenance of tobacco smoking. However, other constituents in tobacco may contribute to …

Introduction Although nicotine is the primary reinforcing constituent in cigarettes, there is
evidence that other constituents in cigarette smoke may interact with nicotine to reinforce …

Smoking tobacco is highly addictive and a leading preventable cause of death. The main
addictive constituent is nicotine; consequently it has been administered to laboratory …

Rationale: Nicotine, a tobacco alkaloid, is known to be important in the acquisition and
maintenance of tobacco smoking. Nornicotine, an active nicotine metabolite, stimulates …

Tobacco use has one of the highest rates of addiction of any abused drug. Paradoxically, in
animal models, nicotine appears to be a weak reinforcer. We report here that the inhibition of …