Sex and gender differences in neurodegenerative diseases: challenges for therapeutic opportunities

A Bianco, Y Antonacci, M Liguori - International journal of molecular …, 2023 - mdpi.com
The term “neurodegenerative diseases”(NDs) identifies a group of heterogeneous diseases
characterized by progressive loss of selectively vulnerable populations of neurons, which …

Sex: a significant risk factor for neurodevelopmental and neurodegenerative disorders

P Pinares-Garcia, M Stratikopoulos, A Zagato, H Loke… - Brain sciences, 2018 - mdpi.com
Males and females sometimes significantly differ in their propensity to develop neurological
disorders. Females suffer more from mood disorders such as depression and anxiety …

Sex differences in neurodegeneration: the role of the immune system in humans

C Lopez-Lee, L Kodama, L Gan - Biological psychiatry, 2022 - Elsevier
Growing evidence supports significant involvement of immune dysfunction in the etiology of
neurodegenerative diseases, several of which also display prominent sex differences across …

[HTML][HTML] Impact of sex on neuroimmune contributions to Parkinson's disease

M Bourque, M Morissette, D Soulet, T Di Paolo - Brain Research Bulletin, 2023 - Elsevier
Parkinson's disease (PD) is the second most common neurodegenerative disorder after
Alzheimer's disease. Inflammation has been observed in both the idiopathic and familial …

Sex differences in Alzheimer disease—the gateway to precision medicine

MT Ferretti, MF Iulita, E Cavedo, PA Chiesa… - Nature Reviews …, 2018 - nature.com
Alzheimer disease (AD) is characterized by wide heterogeneity in cognitive and behavioural
syndromes, risk factors and pathophysiological mechanisms. Addressing this phenotypic …

Sex differences in Alzheimer's disease: Understanding the molecular impact

CA Toro, L Zhang, J Cao, D Cai - Brain research, 2019 - Elsevier
Alzheimer's disease (AD) is a common neurodegenerative disorder that presents with
cognitive impairment and behavioral disturbance. Approximately 5.5 million people in the …

Alzheimer's pathogenic mechanisms and underlying sex difference

D Zhu, A Montagne, Z Zhao - Cellular and Molecular Life Sciences, 2021 - Springer
AD is a neurodegenerative disease, and its frequency is often reported to be higher for
women than men: almost two-thirds of patients with AD are women. One prevailing view is …

Sex and gender differences in Alzheimer's disease, Parkinson's disease, and Amyotrophic Lateral Sclerosis: A narrative review

A Nicoletti, R Baschi, CE Cicero, S Iacono… - Mechanisms of ageing …, 2023 - Elsevier
Abstract Neurodegenerative diseases (NDs), including Alzheimer's disease (AD),
Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS), exhibit high phenotypic …

Genetics, sex, and gender

C Reale, F Invernizzi, C Panteghini… - Journal of …, 2023 - Wiley Online Library
This review aims to give an overview of what has been discovered so far and what still
needs to be analyzed about how sex and gender affect the disease development. These two …

Exploring sex differences: insights into gene expression, neuroanatomy, neurochemistry, cognition, and pathology

MS Lafta, J Mwinyi, O Affatato, G Rukh… - Frontiers in …, 2024 - frontiersin.org
Increased knowledge about sex differences is important for development of individualized
treatments against many diseases as well as understanding behavioral and pathological …