Sickle cell disease (SCD) is a heterogeneous disorder, with clinical manifestations including
chronic haemolysis, an increased susceptibility to infections and vaso-occlusive …

Introduction: Sickle cell disease (SCD) represents one of the most common monogenic
blood disorders worldwide, with an incidence of over 300,000 newborns affected per year …

Sickle cell disease (SCD) is a group of inherited blood disorders that affect the shape and
function of red blood cells (RBCs). RBCs are responsible for carrying oxygen throughout the …

Sickle cell disease (SCD) is a heterogeneous inherited disorder of hemoglobin that causes
chronic hemolytic anemia, vaso-occlusion, and endothelial dysfunction. These physiologic …

Objectives: Identify the epidemiology of sickle cell disease. Describe the different types of
sickle cell crises. Review the treatment and management options available for sickle cell …

Sickle cell disease is thought to affect 1/2000 births in the UK, with 12 500 affected patients
across the country (NHS Sickle Cell and Thalassaemia Screening Programme, 2010) …

Sickle-cell disease (SCD) is now a common condition in the UK and other European
countries. This is a consequence of the recent influx of immigrants from parts of the world …

Sickle cell disease (SCD) is a pleiotropic genetic disorder of hemoglobin that has profound
multiorgan effects. The low prevalence of SCD (∼ 100,000/US) has limited progress in …

Sickle cell disease (SCD) is an autosomal recessive genetic condition that alters the shape
and function of the hemoglobin molecule in red blood cells. While the overall survival rate …

As more children are appropriately being diagnosed, the burden of sickle cell disease is
increasing greatly in Africa and in high-resource countries such as the United States and …