The dynamic interplay between pro-death and pro-survival Bcl-2 family proteins is
responsible for a cell's fate. Due to the recognized relevance of this family in cancer …

Antiapoptotic BCL2 proteins play a major role in tumor cell survival. Hence, BCL2 inhibitors
have been developed as direct inducers of apoptosis. ABT-199 (venetoclax) received …

Impaired apoptosis plays a central role in cancer development and limits the efficacy of
conventional cytotoxic therapies. Deepening understanding of how opposing factions of the …

Simple Summary Apoptosis, a programmed form of cell death, represents the main
mechanism by which cells die. Such phenomenon is highly regulated by the BCL-2 family of …

Mutations that impair apoptosis contribute to cancer development and reduce the
effectiveness of conventional anti-cancer therapies. These insights and understanding of …

The removal of cells by apoptosis is an essential process regulating tissue homeostasis.
Cancer cells acquire the ability to circumvent apoptosis and survive in an unphysiological …

Highlights•Antiapoptotic proteins of the Bcl-2 family are targets for anticancer drugs.•BH3
mimetics inhibit antiapoptotic proteins and exert in vitro antitumor activity.•Some BH3 …

Escape from apoptosis is a key attribute of tumour cells and facilitates chemo-resistance.
The 'BCL-2-regulated'or 'intrinsic'apoptotic pathway integrates stress and survival signalling …

Apoptosis is a form of programmed cell death that is regulated by the balance between
prosurvival and proapoptotic BCL-2 protein family members. Evasion of apoptosis is a …

Members of the B cell lymphoma 2 (BCL-2) gene family have a central role in regulating
programmed cell death by controlling pro-apoptotic and anti-apoptotic intracellular signals …