Emphysema is one of the pathological hallmarks of chronic obstructive pulmonary disease.
We have recently reported that radiofrequency therapy improves lung function in rodent …

For clinical translation, preclinical data using large animal models is necessary. However,
51 papers describing an emphysema model in pigs, which are anatomically and …

Emphysema is a common phenotype of chronic obstructive pulmonary disease (COPD).
Although resection of emphysematous tissue can improve lung mechanics, it is invasive and …

Progressive emphysema often leads to end-stage lung disease. Most mouse models of
emphysema are typically modest (ie cigarette smoke exposure), and changes over time are …

OBJECTIVES Emphysema affects millions of patients worldwide. Cell transplantation and
tissue engineering are promising approaches for the regeneration of gas exchange tissue in …

COPD is characterised by the destruction of lung tissue resulting in alveolar tissue
destruction, enlargement of alveolar spaces, poor gas exchange and airway collapse due to …

Many experimental models have been proposed to study the pathophysiological features of
emphysema, as well as to search for new therapeutic approaches for acute or chronically …

The purpose of this study was to determine how the initial distribution of elastase in mouse
lungs determines the time course of tissue destruction and how structural heterogeneity at …

Pulmonary exposure of rodents to porcine pancreatic elastase (PPE) induces lesions that
morphologically resemble human panacinar emphysema. However, there has been little …

Methods Nine male mongrel dogs (28-60 kg) were anesthetized with sodium thiopental (25
mg/kg), intubated with a radiopaque, double lumen endotracheal tube and anesthesia …