Herein, we review advances in understanding a group of disorders collectively known as
TAR-DNA binding protein 43 (TDP-43) proteinopathies since the report that TDP-43 is the …

In this review, we summarize recent advances in understanding frontotemporal lobar
degeneration (FTLD), amyotrophic lateral sclerosis (ALS) and related neurodegenerative …

The rapid confirmation of the initial report by Neumann et al.(Science 314: 130–133, 2006)
that transactive response (TAR)-DNA-binding protein 43 (TDP-43) is the major disease …

Over the past decade, it has become clear that there is a significant overlap in the clinical
spectrum of frontotemporal lobar degeneration and amyotrophic lateral sclerosis (ALS). The …

The presence of lower molecular weight species comprising the C-terminal region of TAR
DNA-binding protein 43 (TDP-43) is a characteristic of TDP-43 proteinopathy in amyotrophic …

Aggregation of misfolded TAR DNA-binding protein 43 (TDP-43) is a striking hallmark of
neurodegenerative processes that are observed in several neurological disorders, and in …

The identification of TDP-43 as the major component of the pathologic inclusions in most
forms of sporadic and familial frontotemporal lobar degeneration with ubiquitin-positive …

TAR DNA binding protein of 43 kDa (TDP-43) is a major component of the ubiquitin-positive
inclusions found in the brain of patients with frontotemporal lobar degeneration (FTLD-U) …

In 2006, TAR DNA-binding protein 43 (TDP-43), a highly conserved nuclear protein, was
identified as the major disease protein in amyotrophic lateral sclerosis (ALS) and in the most …

Ever since the significance of pathological 43-kDa transactivating responsive sequence
DNA-binding protein (TDP-43) for human disease has been recognized in amyotrophic …