Systematic tracking of disrupted modules identifies significant genes and pathways in hepatocellular carcinoma

MH Zhang, QH Shen, ZM Qin… - Oncology …, 2016 - spandidos-publications.com
The objective of the present study is to identify significant genes and pathways associated
with hepatocellular carcinoma (HCC) by systematically tracking the dysregulated modules of …

Identification of disrupted pathways associated with colon cancer based on combining protein–protein interactions and pathway data

J He, W Liu - Journal of Cancer Research and Therapeutics, 2018 - journals.lww.com
Objective: The objective of this paper was to identify the disrupted pathways associated with
colon cancer at a network level based on protein–protein interaction (PPI) network and …

[HTML][HTML] Dissecting the expression landscape of cytochromes P450 in hepatocellular carcinoma: towards novel molecular biomarkers

CM Brodeur, P Thibault, M Durand, JP Perreault… - Genes & …, 2019 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths
around the world. Recent advances in genomic technologies have allowed the identification …

Integrated bioinformatics analysis reveals key candidate genes and pathways associated with clinical outcome in hepatocellular carcinoma

Y Li, R Chen, J Yang, S Mo, K Quek, CH Kok… - Frontiers in …, 2020 - frontiersin.org
Hepatocellular carcinoma (HCC) accounts for approximately 85–90% of all liver cancer
cases and has poor relapse-free survival. There are many gene expression studies that …

Integrative module analysis of HCC gene expression landscapes

H Li, N Wei, Y Ma, X Wang… - Experimental and …, 2020 - spandidos-publications.com
Despite hepatocellular carcinoma (HCC) being a common cancer globally, its initiation and
progression are not well understood. The present study was designed to investigate the hub …

Identifying hepatocellular carcinoma driver genes by integrative pathway crosstalk and protein interaction network

W Chen, J Jiang, PP Wang, L Gong, J Chen… - DNA and cell …, 2019 - liebertpub.com
In this study, we mined out hepatocellular carcinoma (HCC) driver genes from MEDLINE
literatures by bioinformatics methods of pathway crosstalk and protein interaction network …

Identification of key genes and pathways in hepatocellular carcinoma using bioinformatics analysis.

S Yin, X Zhang, J Du, Y Chen - 2020 - cabidigitallibrary.org
Hepatocellular carcinoma (HCC) is one of the cancers species with high mortality rates. The
purpose of this study is to provide more data for the underlying mechanism of HCC, which …

Identification of HCC-related genes based on differential partial correlation network

Y Gao, X Chang, J Xia, S Sun, Z Mu, X Liu - Frontiers in Genetics, 2021 - frontiersin.org
Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related death,
but its pathogenesis is still unclear. As the disease is involved in multiple biological …

Differential coexpression network modules observed in human hepatocellular carcinoma progression

H Yu, Z Zhao - BMC Bioinformatics, 2013 - Springer
Background While an understanding of the human interactome is within attainable reach [1],
an impending challenge is to uncover the condition-specific dynamics of the protein-protein …

Severely impaired and dysregulated cytochrome P450 expression and activities in hepatocellular carcinoma: implications for personalized treatment in patients

T Yan, L Lu, C Xie, J Chen, X Peng, L Zhu… - Molecular cancer …, 2015 - AACR
This study aims to systematically determine the activities and expressions of cytochrome
P450s (CYP) in hepatocellular carcinoma (HCC) patients to support their optimal use in …