Optogenetic activation of brainstem serotonergic neurons induces persistent pain sensitization
YQ Cai, W Wang, YY Hou, ZZ Pan - Molecular pain, 2014 - journals.sagepub.com
Background: The rostral ventromedial medulla (RVM) is a key brainstem structure that
conveys powerful descending influence of the central pain-modulating system on spinal …
conveys powerful descending influence of the central pain-modulating system on spinal …
Cortical pain processing in the rat anterior cingulate cortex and primary somatosensory cortex
Z Xiao, E Martinez, PM Kulkarni, Q Zhang… - Frontiers in Cellular …, 2019 - frontiersin.org
Pain is a complex multidimensional experience encompassing sensory-discriminative,
affective-motivational and cognitive-emotional components mediated by different neural …
affective-motivational and cognitive-emotional components mediated by different neural …
Divergent modulation of nociception by glutamatergic and GABAergic neuronal subpopulations in the periaqueductal gray
The ventrolateral periaqueductal gray (vlPAG) constitutes a major descending pain
modulatory system and is a crucial site for opioid-induced analgesia. A number of previous …
modulatory system and is a crucial site for opioid-induced analgesia. A number of previous …
Cortical and subcortical modulation of pain
MD Felice, MH Ossipov - Pain management, 2016 - Taylor & Francis
Pain is more than merely nociception and response, but rather it encompasses emotional,
behavioral and cognitive components that make up the pain experience. With the recent …
behavioral and cognitive components that make up the pain experience. With the recent …
Different brain circuitries mediating controllable and uncontrollable pain
Uncontrollable, compared with controllable, painful stimulation can lead to increased pain
perception and activation in pain-processing brain regions, but it is currently unknown which …
perception and activation in pain-processing brain regions, but it is currently unknown which …
Decreased dopaminergic inhibition of pyramidal neurons in anterior cingulate cortex maintains chronic neuropathic pain
Pyramidal neurons in the anterior cingulate cortex (ACC), a prefrontal region involved in
processing the affective components of pain, display hyperexcitability in chronic neuropathic …
processing the affective components of pain, display hyperexcitability in chronic neuropathic …
Contribution of the activation of satellite glia in sensory ganglia to pathological pain
M Takeda, M Takahashi, S Matsumoto - Neuroscience & Biobehavioral …, 2009 - Elsevier
Peripheral tissue injury/inflammation can alter the properties of somatic sensory pathways,
resulting in behavioral hypersensitivity and pathological and/or chronic pain, including …
resulting in behavioral hypersensitivity and pathological and/or chronic pain, including …
Pain networks from the inside: spatiotemporal analysis of brain responses leading from nociception to conscious perception
H Bastuji, M Frot, C Perchet, M Magnin… - Human brain …, 2016 - Wiley Online Library
Conscious perception of painful stimuli needs the contribution of an extensive cortico‐
subcortical network, and is completed in less than one second. While initial activities in …
subcortical network, and is completed in less than one second. While initial activities in …
Oxytocin promotes prefrontal population activity via the PVN-PFC pathway to regulate pain
Y Liu, A Li, C Bair-Marshall, H Xu, HJ Jee, E Zhu… - Neuron, 2023 - cell.com
Neurons in the prefrontal cortex (PFC) can provide top-down regulation of sensory-affective
experiences such as pain. Bottom-up modulation of sensory coding in the PFC, however …
experiences such as pain. Bottom-up modulation of sensory coding in the PFC, however …
[HTML][HTML] Physiology, nociception
SA Armstrong, MJ Herr - 2019 - europepmc.org
Nociception provides a means of neural feedback that allows the central nervous system
(CNS) to detect and avoid noxious and potentially damaging stimuli in both active and …
(CNS) to detect and avoid noxious and potentially damaging stimuli in both active and …