Neurons in the prefrontal cortex (PFC) can provide top-down regulation of sensory-affective
experiences such as pain. Bottom-up modulation of sensory coding in the PFC, however …

Neuropathic pain is one of the most common and notorious neurological diseases. The
changes in cerebral structures after nerve injury and the corresponding contributions to …

A hallmark feature of chronic pain is its ability to impact other sensory and affective
experiences. It is notably associated with hypersensitivity at the site of tissue injury. It is less …

Pain is a highly complex and subjective experience that is not linearly related to the
nociceptive input. What is clear from anecdotal reports over the centuries and more recently …

Various mechanisms at peripheral, spinal and/or supraspinal levels may underlie
neuropathic pain. The nervous system's capacity for long-term reorganisation and chronic …

Cognitive self-regulation can strongly modulate pain and emotion. However, it is unclear
whether self-regulation primarily influences primary nociceptive and affective processes or …

Pain perception is essential for survival and can be amplified or suppressed by
expectations, experiences, and context. The neural mechanisms underlying bidirectional …

There are two basic categories of pain: physiological pain, which serves an important
protective function, and pathological pain, which can have a major negative impact on …

Pain is an integrated sensory and affective experience. Cortical mechanisms of sensory and
affective integration, however, remain poorly defined. Here, we investigate the projection …

Chronic neuropathic pain is a major morbidity of neural injury, yet its mechanisms are
incompletely understood. Hypersensitivity to previously non-noxious stimuli (allodynia) is a …