Early adversity increases risk for developing psychopathology. Epigenetic modification of
stress reactivity genes is a likely mechanism contributing to this risk. The glucocorticoid …

Background A history of early adverse experiences is an important risk factor for adult
psychopathology. Changes in stress sensitivity and functioning of the hypothalamic-pituitary …

Epigenetic modulations are a hypothesized link between environmental factors and the
development of psychiatric disorders. Research has suggested that patients with depression …

Stress, particularly when experienced early in life, can have profound implications for mental
health. Previous research covering various tissues such as the brain, suggests that the …

Accumulating evidence suggests that early adversity is linked to methylation of the
glucocorticoid receptor (GR) gene, NR3C1, which is a key regulator of the hypothalamic …

Childhood maltreatment, through epigenetic modification of the glucocorticoid receptor gene
(NR3C1), influences the hypothalamic–pituitary–adrenal axis (HPA axis). We investigated …

The early-life social environment can induce stable changes that influence
neurodevelopment and mental health. Research focused on early-life adversity revealed …

Stress early in life is a known risk factor for the development of affective disorders later in life.
Epigenetic mechanisms, such as DNA methylation, may have an important role in mediating …

The present study examined the effect of various dimensions of child maltreatment (ie,
developmental timing of maltreatment, number of maltreatment subtypes, and chronicity of …

Depression is associated with alterations in hypothalamic–pituitary–adrenal (HPA) axis
activity. A proposed mechanism to explain these alterations are changes in DNA methylation …