Chemically modified biomacromolecules─ ie, proteins, nucleic acids, glycans, and lipids─
have become crucial tools in chemical biology. They are extensively used not only to …

Using a chemical approach to crosslink functionally versatile bioeffectors (such as peptides)
to native proteins of interest (POI) directly inside a living cell is a useful toolbox for chemical …

Reversible photocontrol of peptide and protein conformation could prove to be a powerful
tool for probing function in diverse biological systems. Here, we report reversible …

Bioorthogonal chemistry has been a powerful tool in chemical biology. It can facilitate the
study of biomolecules in their native environments and enables targeted delivery and …

Recent developments in the design of bifunctional and activatable photosensitizers
rejuvenate the aging field of photodynamic sensitization and photodynamic therapy. While …

Abscisic acid (ABA) was chemically modified with a photocaging group to promote photo‐
induced protein dimerization. This photocontrolled chemically induced dimerization (CID) …

Nonselective cell damage remains a significant limitation of radiation therapies in cancer.
Decades of successful integration of radiation therapies with other medicinal chemistry …

Development of methodologies for optically triggered protein degradation enables the study
of dynamic protein functions, such as those involved in cell signaling, that are difficult to be …

Visualization in biology has been greatly facilitated by the use of fluorescent proteins as in-
cell probes. The genes coding for these wavelength-tunable proteins can be readily fused …

Biological processes are naturally regulated with high spatial and temporal resolution at the
molecular, cellular, and systems level. To control and study processes with the same …