Efficacy of perioperative chemotherapy for resectable pancreatic adenocarcinoma: a phase 2 randomized clinical trial

DPS Sohal, M Duong, SA Ahmad, NS Gandhi… - JAMA …, 2021 - jamanetwork.com
Importance Clinical outcomes after curative treatment of resectable pancreatic ductal
adenocarcinoma (PDA) remain suboptimal. To assess the potential of early control of …

Optimal duration and timing of adjuvant chemotherapy after definitive surgery for ductal adenocarcinoma of the pancreas: ongoing lessons from the ESPAC-3 study

JW Valle, D Palmer, R Jackson, T Cox… - Journal of clinical …, 2014 - ascopubs.org
Purpose Adjuvant chemotherapy improves patient survival rates after resection for
pancreatic adenocarcinoma, but the optimal duration and time to initiate chemotherapy is …

[HTML][HTML] Perioperative or only adjuvant gemcitabine plus nab-paclitaxel for resectable pancreatic cancer (NEONAX)—a randomized phase II trial of the AIO pancreatic …

T Seufferlein, W Uhl, M Kornmann, H Algül, H Friess… - Annals of …, 2023 - Elsevier
Background Data on perioperative chemotherapy in resectable pancreatic ductal
adenocarcinoma (rPDAC) are limited. NEONAX examined perioperative or adjuvant …

Overall survival is increased among stage III pancreatic adenocarcinoma patients receiving neoadjuvant chemotherapy compared to surgery first and adjuvant …

CR Shubert, JR Bergquist, RT Groeschl… - Surgery, 2016 - Elsevier
Background Outcomes of neoadjuvant systemic therapy versus an upfront operation for
clinical, stage III pancreatic adenocarcinoma remain poorly defined. Our aim was to …

Completion of adjuvant chemotherapy after upfront surgical resection for pancreatic cancer is uncommon yet associated with improved survival

AM Altman, K Wirth, S Marmor, E Lou, K Chang… - Annals of surgical …, 2019 - Springer
Background Multiple trials have demonstrated a survival benefit for adjuvant chemotherapy
after resection of pancreatic adenocarcinoma. This study aimed to identify the rate for …

[HTML][HTML] Adjuvant gemcitabine versus NEOadjuvant gemcitabine/oxaliplatin plus adjuvant gemcitabine in resectable pancreatic cancer: a randomized multicenter …

S Heinrich, B Pestalozzi, M Lesurtel, F Berrevoet… - BMC cancer, 2011 - Springer
Background Despite major improvements in the perioperative outcome of pancreas surgery,
the prognosis of pancreatic cancer after curative resection remains poor. Adjuvant …

[HTML][HTML] Neoadjuvant chemotherapy versus surgery first for resectable pancreatic cancer (Norwegian Pancreatic Cancer Trial-1 (NorPACT-1))–study protocol for a …

KJ Labori, K Lassen, D Hoem, JE Grønbech… - BMC surgery, 2017 - Springer
Background Pancreatic cancer is the fourth leading cause of cancer-related death. While
surgical resection remains the foundation for potentially curative treatment, survival benefit is …

Adjuvant chemotherapy with gemcitabine and long-term outcomes among patients with resected pancreatic cancer: the CONKO-001 randomized trial

H Oettle, P Neuhaus, A Hochhaus, JT Hartmann… - Jama, 2013 - jamanetwork.com
Importance The prognosis for patients with pancreatic cancer is poor, even after resection
with curative intent. Gemcitabine-based chemotherapy is standard treatment for advanced …

Preoperative therapy and pancreatoduodenectomy for pancreatic ductal adenocarcinoma: a 25-year single-institution experience

JM Cloyd, MHG Katz, L Prakash… - Journal of …, 2017 - Elsevier
Background The purpose of this study was to evaluate a single-institution experience with
delivery of preoperative therapy to patients with pancreatic ductal adenocarcinoma (PDAC) …

Patterns of recurrence after resection of pancreatic ductal adenocarcinoma: a secondary analysis of the ESPAC-4 randomized adjuvant chemotherapy trial

RP Jones, EE Psarelli, R Jackson, P Ghaneh… - JAMA …, 2019 - jamanetwork.com
Importance The patterns of disease recurrence after resection of pancreatic ductal
adenocarcinoma with adjuvant chemotherapy remain unclear. Objective To define patterns …