Although the oocyte is the largest cell in the body and an unavoidable phase in life, its
physiology is still poorly understood, and other cell types provide little insight into its unique …

A follicular spike in cyclic AMP (cAMP) and its subsequent degradation to AMP promotes
oocyte maturation and ovulation. In vitro matured (IVM) oocytes do not receive the cAMP …

During mammalian oocyte maturation there are marked changes in the distribution of
mitochondria that supply the majority of the cellular ATP. Such redistribution of mitochondria …

Oocyte maturation is a complex process involving nuclear and cytoplasmic maturation. The
nuclear maturation is a chromosomal segregation and the cytoplasmic maturation involves …

Oocyte maturation is a final step of gamete development that follows a prolonged period of
cell growth within a growing follicle. Unlike oocyte growth that takes several weeks or …

Fertilization activates development by stimulating a plethora of ATP consuming processes
that must be provided for by an up-regulation of energy production in the zygote. Sperm …

The relationship between the ATP content of mature human oocytes and developmental
potential after uterine transfer of sibling embryos was examined in 20 non-male factor in …

Mammalian eggs and embryos rely upon mitochondrial ATP production to survive and
proceed through preimplantation development. Ca2+ oscillations at fertilization have been …

Mitochondrial bioenergetics in mammalian oocytes has not been sufficiently characterized.
In this study, the function of oxidative phosphorylation (OXPHOS), a major pathway in …

The oocyte requires a vast supply of energy after fertilization to support critical events such
as spindle formation, chromatid separation, and cell division. Until blastocyst implantation …