The zinc finger protein early growth response 1 (Egr 1) is a transcriptional activator involved
in the regulation of growth and differentiation. We show here that a constitutive active mutant …

Amino acid (AA) limitation in mammalian cells triggers a collection of signaling cascades
jointly referred to as the AA response (AAR). In human HepG2 hepatocellular carcinoma, the …

Endoplasmic reticulum (ER) stress activates three principal signaling pathways, collectively
known as the unfolded protein response, leading to translational and transcriptional control …

Early growth response-1 (Egr-1) is a Cys2-His2-type zinc-finger transcription factor. A broad
range of extracellular stimuli is capable of activating Egr-1, thus mediating growth …

The early growth response-1 gene (egr-1) encodes a zinc-finger transcription factor Egr-1
and is rapidly inducible by a variety of extracellular stimuli. Anisomycin (ANX), a protein …

Publisher Summary This chapter discusses the early growth response protein (Egr) gene
family and its most extensively characterized member, Egr-1, first identified as an immediate …

Abstract The Ras/Raf/MAP kinase (ERK) pathway is a major signaling pathway induced by
growth factors in mammalian cells. Two other types of mammalian MAP kinases, JNK …

ABSTRACT Early growth response 1 (Egr-1) is a cellular transcription factor involved in
diverse biologic functions. Egr-1 has been associated with Epstein-Barr virus (EBV) …

Egr-1 is a ubiquitous immediate-early gene whose expression is induced by a wide range of
different stimuli. A requirement for egr-1 expression has been demonstrated in pathways …

Growth factor—receptor interactions at the cell surface eventually leading to the
transcriptional activation of immediate early genes is mediated by the mitogen-activated …