Experimental data indicates that soluble vascular endothelial growth factor (VEGF) receptor
1 (sFlt-1) modulates the guidance cues provided to sprouting blood vessels by VEGF-A. To …

Background The spatial distribution of vascular endothelial growth factor A (VEGF) is an
important mediator of vascular patterning. Previous experimental studies in the mouse …

Aims In developing blood vessel networks, the overall level of vessel branching often
correlates with angiogenic sprout initiations, but in some pathological situations, increased …

Blood vessel formation requires the integrated regulation of endothelial cell proliferation and
branching morphogenesis, but how this coordinated regulation is achieved is not well …

Vascular endothelial growth factor (VEGF) signal transduction through the cell surface
receptors VEGFR1 and VEGFR2 regulates angiogenesis—the growth of new capillaries …

Vascular patterning is a key process during development and disease. The diffusive decoy
receptor sVEGFR1 (sFlt1) is a known regulator of endothelial cell behavior, yet the …

Sprouting angiogenesis is critical to blood vessel formation, but the cellular and molecular
controls of this process are poorly understood. We used time-lapse imaging of green …

The vascular endothelial growth factor receptors (VEGFR) play a significant role in
angiogenesis, the formation of new blood vessels from existing vasculature. Systems …

Vascular endothelial growth factor (VEGF) is a potent cytokine that binds to specific
receptors on the endothelial cells lining blood vessels. The signaling cascade triggered …

Blood vessel networks form via sprouting of endothelial cells from parent vessels. Extrinsic
cues guide sprouts after they leave the initiation site, but these cues are likely insufficient to …