[HTML][HTML] Apicoplast-Localized Lysophosphatidic Acid Precursor Assembly Is Required for Bulk Phospholipid Synthesis in Toxoplasma gondii and Relies on an Algal …

S Amiar, JI MacRae, DL Callahan, D Dubois… - PLoS …, 2016 - journals.plos.org
Most apicomplexan parasites possess a non-photosynthetic plastid (the apicoplast), which
harbors enzymes for a number of metabolic pathways, including a prokaryotic type II fatty …

[HTML][HTML] Apicoplast and endoplasmic reticulum cooperate in fatty acid biosynthesis in apicomplexan parasite Toxoplasma gondii

S Ramakrishnan, MD Docampo, JI MacRae… - Journal of Biological …, 2012 - ASBMB
Apicomplexan parasites are responsible for high impact human diseases such as malaria,
toxoplasmosis, and cryptosporidiosis. These obligate intracellular pathogens are dependent …

[HTML][HTML] Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage

S Dass, S Shunmugam, L Berry, CS Arnold… - Nature …, 2021 - nature.com
Apicomplexa are obligate intracellular parasites responsible for major human diseases.
Their intracellular survival relies on intense lipid synthesis, which fuels membrane …

[HTML][HTML] Acquisition of exogenous fatty acids renders apicoplast-based biosynthesis dispensable in tachyzoites of Toxoplasma

X Liang, J Cui, X Yang, N Xia, Y Li, J Zhao… - Journal of Biological …, 2020 - ASBMB
Toxoplasma gondii is a common protozoan parasite that infects a wide range of hosts,
including livestock and humans. Previous studies have suggested that the type 2 fatty acid …

Apicoplast fatty acid synthesis is essential for pellicle formation at the end of cytokinesis in Toxoplasma gondii

ÉS Martins-Duarte, M Carias… - Journal of cell …, 2016 - journals.biologists.com
The apicomplexan protozoan Toxoplasma gondii, the causative agent of toxoplasmosis,
harbors an apicoplast, a plastid-like organelle with essential metabolic functions. Although …

Apicoplast fatty acid synthesis is essential for organelle biogenesis and parasite survival in Toxoplasma gondii

J Mazumdar, E H. Wilson, K Masek… - Proceedings of the …, 2006 - National Acad Sciences
Apicomplexan parasites are the cause of numerous important human diseases including
malaria and AIDS-associated opportunistic infections. Drug treatment for these diseases is …

[HTML][HTML] Two apicoplast dwelling glycolytic enzymes provide key substrates for metabolic pathways in the apicoplast and are critical for Toxoplasma growth

Z Niu, S Ye, J Liu, M Lyu, L Xue, M Li, C Lyu… - PLoS …, 2022 - journals.plos.org
Many apicomplexan parasites harbor a non-photosynthetic plastid called the apicoplast,
which hosts important metabolic pathways like the methylerythritol 4-phosphate (MEP) …

The intracellular parasite Toxoplasma gondii depends on the synthesis of long‐chain and very long‐chain unsaturated fatty acids not supplied by the host cell

S Ramakrishnan, MD Docampo… - Molecular …, 2015 - Wiley Online Library
Apicomplexa are parasitic protozoa that cause important human diseases including malaria,
cryptosporidiosis and toxoplasmosis. The replication of these parasites within their target …

Toxoplasma gondii acyl-lipid metabolism: de novo synthesis from apicoplast-generated fatty acids versus scavenging of host cell precursors

C Bisanz, O Bastien, D Grando, J Jouhet… - Biochemical …, 2006 - portlandpress.com
Toxoplasma gondii is an obligate intracellular parasite that contains a relic plastid, called the
apicoplast, deriving from a secondary endosymbiosis with an ancestral alga. Metabolic …

[HTML][HTML] Phosphatidylinositol synthesis, its selective salvage, and inter-regulation of anionic phospholipids in Toxoplasma gondii

B Ren, P Kong, F Hedar, JF Brouwers… - Communications …, 2020 - nature.com
Phosphatidylinositol (PtdIns) serves as an integral component of eukaryotic membranes;
however, its biosynthesis in apicomplexan parasites remains poorly understood. Here we …