[HTML][HTML] Apicoplast-Localized Lysophosphatidic Acid Precursor Assembly Is Required for Bulk Phospholipid Synthesis in Toxoplasma gondii and Relies on an Algal …
S Amiar, JI MacRae, DL Callahan, D Dubois… - PLoS …, 2016 - journals.plos.org
Most apicomplexan parasites possess a non-photosynthetic plastid (the apicoplast), which
harbors enzymes for a number of metabolic pathways, including a prokaryotic type II fatty …
harbors enzymes for a number of metabolic pathways, including a prokaryotic type II fatty …
[HTML][HTML] Apicoplast and endoplasmic reticulum cooperate in fatty acid biosynthesis in apicomplexan parasite Toxoplasma gondii
S Ramakrishnan, MD Docampo, JI MacRae… - Journal of Biological …, 2012 - ASBMB
Apicomplexan parasites are responsible for high impact human diseases such as malaria,
toxoplasmosis, and cryptosporidiosis. These obligate intracellular pathogens are dependent …
toxoplasmosis, and cryptosporidiosis. These obligate intracellular pathogens are dependent …
[HTML][HTML] Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage
Apicomplexa are obligate intracellular parasites responsible for major human diseases.
Their intracellular survival relies on intense lipid synthesis, which fuels membrane …
Their intracellular survival relies on intense lipid synthesis, which fuels membrane …
[HTML][HTML] Acquisition of exogenous fatty acids renders apicoplast-based biosynthesis dispensable in tachyzoites of Toxoplasma
X Liang, J Cui, X Yang, N Xia, Y Li, J Zhao… - Journal of Biological …, 2020 - ASBMB
Toxoplasma gondii is a common protozoan parasite that infects a wide range of hosts,
including livestock and humans. Previous studies have suggested that the type 2 fatty acid …
including livestock and humans. Previous studies have suggested that the type 2 fatty acid …
Apicoplast fatty acid synthesis is essential for pellicle formation at the end of cytokinesis in Toxoplasma gondii
ÉS Martins-Duarte, M Carias… - Journal of cell …, 2016 - journals.biologists.com
The apicomplexan protozoan Toxoplasma gondii, the causative agent of toxoplasmosis,
harbors an apicoplast, a plastid-like organelle with essential metabolic functions. Although …
harbors an apicoplast, a plastid-like organelle with essential metabolic functions. Although …
Apicoplast fatty acid synthesis is essential for organelle biogenesis and parasite survival in Toxoplasma gondii
J Mazumdar, E H. Wilson, K Masek… - Proceedings of the …, 2006 - National Acad Sciences
Apicomplexan parasites are the cause of numerous important human diseases including
malaria and AIDS-associated opportunistic infections. Drug treatment for these diseases is …
malaria and AIDS-associated opportunistic infections. Drug treatment for these diseases is …
[HTML][HTML] Two apicoplast dwelling glycolytic enzymes provide key substrates for metabolic pathways in the apicoplast and are critical for Toxoplasma growth
Z Niu, S Ye, J Liu, M Lyu, L Xue, M Li, C Lyu… - PLoS …, 2022 - journals.plos.org
Many apicomplexan parasites harbor a non-photosynthetic plastid called the apicoplast,
which hosts important metabolic pathways like the methylerythritol 4-phosphate (MEP) …
which hosts important metabolic pathways like the methylerythritol 4-phosphate (MEP) …
The intracellular parasite Toxoplasma gondii depends on the synthesis of long‐chain and very long‐chain unsaturated fatty acids not supplied by the host cell
S Ramakrishnan, MD Docampo… - Molecular …, 2015 - Wiley Online Library
Apicomplexa are parasitic protozoa that cause important human diseases including malaria,
cryptosporidiosis and toxoplasmosis. The replication of these parasites within their target …
cryptosporidiosis and toxoplasmosis. The replication of these parasites within their target …
Toxoplasma gondii acyl-lipid metabolism: de novo synthesis from apicoplast-generated fatty acids versus scavenging of host cell precursors
Toxoplasma gondii is an obligate intracellular parasite that contains a relic plastid, called the
apicoplast, deriving from a secondary endosymbiosis with an ancestral alga. Metabolic …
apicoplast, deriving from a secondary endosymbiosis with an ancestral alga. Metabolic …
[HTML][HTML] Phosphatidylinositol synthesis, its selective salvage, and inter-regulation of anionic phospholipids in Toxoplasma gondii
B Ren, P Kong, F Hedar, JF Brouwers… - Communications …, 2020 - nature.com
Phosphatidylinositol (PtdIns) serves as an integral component of eukaryotic membranes;
however, its biosynthesis in apicomplexan parasites remains poorly understood. Here we …
however, its biosynthesis in apicomplexan parasites remains poorly understood. Here we …