Infection with Cryptococcus neoformans begins when desiccated yeast cells or spores are
inhaled and lodge in the alveoli of the lungs. A subset of cryptococcal cells in the lungs …

The human fungal pathogen Cryptococcus neoformans produces an enlarged “titan” cell
morphology when exposed to the host pulmonary environment. Titan cells exhibit traits that …

Cryptococcus neoformans is a human fungal pathogen that often causes infections in
immunocompromised individuals. Upon inhalation into the lungs C. neoformans …

The pathogenic fungus Cryptococcus neoformans exhibits morphological changes in cell
size during lung infection, producing both typical size 5 to 7 μm cells and large titan cells (> …

Highlights•Cryptococcus has an unusual morphological transition in vivo to generate
enlarged titan cells.•Titan cells are greater than 15 μm in diameter, have a thick cell wall …

Cryptococcus neoformans is a pathogenic yeast that can form titan cells in the lungs, which
are fungal cells of abnormal enlarged size. Little is known about the factors that trigger titan …

The titan cell is a recently described morphological form of the pathogenic fungus
Cryptococcus neoformans. Occurring during the earliest stages of lung infection, titan cells …

Cryptococcus neoformans is an encapsulated pathogenic yeast that can change the size of
the cells during infection. In particular, this process can occur by enlarging the size of the …

Members of the Cryptococcus species complex stand out by unique virulence factors that
allowed evolutionary transition to pathogenesis. Among the factors contributing to …

Fungal cells change shape in response to environmental stimuli, and these morphogenic
transitions drive pathogenesis and niche adaptation. For example, dimorphic fungi switch …