TGFβ-activated kinase 1 (TAK1), a member of the mitogen-activated protein kinase kinase
kinase (MAP3K) family, is considered a key intermediate in a multitude of innate immune …

Stringent control of NF-κB and mitogen-activated protein kinase (MAPK) signaling is critical
during innate immune responses. TGF-β activated kinase-1 (TAK1) is essential for NF-κB …

Transforming growth factor β-activated kinase 1 (TAK1 or MAP3K7) is a key signaling
component of nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) …

TGF-β activating protein kinase 1 (TAK1) belongs to the MAP kinase kinase kinase (MAP3K)
family. TAK1 is involved in many signaling pathways, especially the innate and adaptive …

Macrophages play diverse roles in tissue homeostasis and immunity, and canonically
activated macrophages are critically associated with acute inflammatory responses. It is …

TAK1 (TGF-β Activated Kinase 1) is a MAPK kinase kinase, which activates the p38-and JNK-
MAPK and NF-κB pathways downstream of receptors such as Toll-Like-, cytokine-and T-cell …

Transforming growth factor β‐activated kinase 1 (TAK1) is a key regulator of the innate
immunity and the proinflammatory signaling pathway. In response to interleukin‐1, tumor …

Abstract TGF-β–activated kinase 1 (TAK1) is known to play vital roles for innate and adaptive
immunity; however, little is known about its potential role in limiting biological responses …

Hematopoietic cell survival and death is critical for development of a functional immune
system. Here, we report that a protein kinase, TAK1, is selectively required for resident …

TAK1, a member of MAPK kinase kinase (MAPKK-K) family, can activate JNK, p38 MAPK,
and NF-κB signaling pathways. Although targeted gene disruption studies have …