1. Tumor types in which a large fraction of patients can be cured. Here we should
differentiate between those patients with advanced disease and those treated in an adjuvant …

Although there has been steady progress with respect to the proportion of patients with
certain types of neoplasms that can be cured with chemotherapy, the fact remains that the …

Resistance to drugs active in the treatment of cancer is one of the most frustrating of all
cancer treatment problems. The magnitude of the problem and its impact on cancer mortality …

Although the use of chemotherapy as a major form of treatment for malignant disease is in its
infancy, its introduction 40 years ago has led to significant advances in treatment of certain …

Systemic therapy with cytotoxic drugs is the basis of most effective treatments of
disseminated cancers. Additionally, adjuvant chemotherapy can offer a significant survival …

Chemotherapy cures a minority of adult tumours (eg Hodgkin's and non-Hodgkin's
lymphoma, acute leukaemia, teratoma) and the majority of childhood tumours. Prolongation …

Where do you begin to look for a recent, authoritative article on the diagnosis or
management of a particular malignancy? The few general oncology textbooks are generally …

This chapter considers mechanisms of resistance and also the ways of overcoming
resistance to chemotherapy in the cancer patient. First it will consider 'apparent'drug …

The management of cancer involves procedures, which include surgery, radiotherapy and
chemotherapy. Development of chemoresistance is a persistent problem during the …

The most informative clinical trials are those in which correlative measurements are being
done to determine if the intended target is, in fact, being affected as expected by the …