MYC is a proto-oncogene regulating a large number of genes involved in a plethora of
cellular functions. Its deregulation results in activation of MYC gene expression and/or an …

MYC regulates a complex biological program by transcriptionally activating and repressing
its numerous target genes. As such, MYC is a master regulator of many processes, including …

Overexpression of MYC is a hallmark of many human cancers. The MYC oncogene has long
been thought to execute its neoplastic functions by acting as a classic transcription factor …

MYC, a key member of the Myc-proto-oncogene family, is a universal transcription amplifier
that regulates almost every physiological process in a cell including cell cycle, proliferation …

MYC is one of the most important oncogenes in cancer. Indeed, MYC is upregulated in 50–
60% of all tumors. MYC overexpression can be achieved through a variety of mechanisms …

MYC overexpression has been implicated in the pathogenesis of most types of human
cancers. MYC is likely to contribute to tumorigenesis by its effects on global gene …

MYC represents a transcription factor with oncogenic potential converting multiple cellular
signals into a broad transcriptional response, thereby controlling the expression of …

The transcription factor and cell growth regulator MYC is potently oncogenic and estimated
to contribute to most cancers. Decades of attempts to therapeutically target MYC directly …

Myc regulates key cellular processes including cell cycle, differentiation, and apoptosis. It
has long been thought to direct these functions by acting solely as a classic transcription …

Abstract MYC proteins (c-MYC, MYCN, and MYCL) regulate processes involved in many if
not all aspects of cell fate. Therefore, it is not surprising that the MYC genes are deregulated …