Molecular basis and therapeutic potential of myostatin on bone formation and metabolism in orthopedic disease

Y Cui, Q Yi, W Sun, D Huang, H Zhang, L Duan… - Biofactors, 2023 - Wiley Online Library
Myostatin, a member of the transforming growth factor‐β (TGF‐β) superfamily, is a key
autocrine/paracrine inhibitor of skeletal muscle growth. Recently, researchers have …

[HTML][HTML] Effects of myokines on bone

H Kaji - BoneKEy reports, 2016 - ncbi.nlm.nih.gov
The links between muscle and bone have been recently examined because of the
increasing number of patients with osteoporosis and sarcopenia. Myokines are skeletal …

Myostatin–the holy grail for muscle, bone, and fat?

B Buehring, N Binkley - Current osteoporosis reports, 2013 - Springer
Myostatin, a member of the transforming growth factor beta (TGF-β) superfamily, was first
described in 1997. Since then, myostatin has gained growing attention because of the …

Myostatin promotes osteoclastogenesis by regulating ccdc50 gene expression and RANKL-induced NF-κB and MAPK pathways

X Zhi, Q Chen, S Song, Z Gu, W Wei, H Chen… - Frontiers in …, 2020 - frontiersin.org
Myostatin is a crucial cytokine that is widely present in skeletal muscle and that negatively
regulates the growth and development of muscle cells. Recent research has shown that …

[HTML][HTML] Myostatin (GDF-8) as a key factor linking muscle mass and skeletal form

MN Elkasrawy, MW Hamrick - Journal of musculoskeletal & …, 2010 - ncbi.nlm.nih.gov
Abstract Myostatin (GDF-8) is a member of the transforming growth factor-beta (TGF-β)
superfamily that is highly expressed in skeletal muscle, and myostatin loss-of-function leads …

Myostatin (GDF-8) inhibits chondrogenesis and chondrocyte proliferation in vitro by suppressing Sox-9 expression

M Elkasrawy, S Fulzele, M Bowser, K Wenger… - Growth …, 2011 - Taylor & Francis
Here, we investigate a possible direct role for myostatin in chondrogenesis. First, we
examined the effects of myostatin on the proliferation of bone marrow stromal cells (BMSCs) …

[HTML][HTML] The elusive role of myostatin signaling for muscle regeneration and maintenance of muscle and bone homeostasis

A Mitra, R Qaisar, B Bose, SP Sudheer - Osteoporosis and sarcopenia, 2023 - Elsevier
Skeletal muscle is one of the leading frameworks of the musculo-skeletal system, which
works in synergy with the bones. Long skeletal muscles provide stability and mobility to the …

[PDF][PDF] Myostatin (GDF-8) as a Therapeutic Target for the Prevention of Osteoporotic Fractures.

MW Hamrick - IBMS BoneKEy, 2010 - triggered.edina.clockss.org
It is widely recognized that myostatin (GDF-8), a member of the transforming growth factor
beta (TGFβ) superfamily of growth and differentiation factors, suppresses muscle growth and …

Deciphering myostatin's regulatory, metabolic, and developmental influence in skeletal diseases

CL Omosule, CL Phillips - Frontiers in Genetics, 2021 - frontiersin.org
Current research findings in humans and other mammalian and non-mammalian species
support the potent regulatory role of myostatin in the morphology and function of muscle as …

[HTML][HTML] Myostatin inhibitors: panacea or predicament for musculoskeletal disorders?

J Suh, YS Lee - Journal of bone metabolism, 2020 - ncbi.nlm.nih.gov
Myostatin, also known as growth differentiation factor 8 (GDF8), is a transforming growth
factor-β (TGF-β) family member that functions to limit skeletal muscle growth. Accordingly …