TAp63 as a guardian of female germ line integrity | Nature Structural & Molecular Biology Skip to
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Cyclophosphamide and doxorubicin lead to premature ovarian insufficiency as an off-target
effect. However, their oocyte death pathway has been debated. Here, we clarified the …

TAp63α has been identified as the major quality control factor in the female germline more
than a decade ago by the group of Frank McKeon. DNA damage in primary oocytes, within …

Studies on oocyte transcriptome are important to understand the biological pathways
involved in oogenesis, totipotence and early embryonic development. Moreover, genes …

It has long been recognised that the immature oocytes stored in the ovary as primordial
follicles are exquisitely sensitive to DNA damaging anti-cancer treatments, including both …

The dichotomy in DNA damage sensitivity of developing mouse oocytes during female germ
line development is striking. Embryonic oocytes withstand hundreds of programmed DNA …

Germ cells are sensitive to genotoxins, and ovarian failure and infertility are major side
effects of chemotherapy in young patients with cancer. Here we describe the c-Abl–TAp63 …

The generation of viable sperm proceeds through a series of coordinated steps, including
germ cell self-renewal, meiotic recombination, and terminal differentiation into functional …

Despite the high importance of protecting the genome in the germline, paradoxically,
hundreds of DNA double strand breaks (DSBs) are generated by SPO11, in meiotic germ …

A core evolutionary function of the p53 family is to protect the genomic integrity of gametes.
However, the role of p73 in the male germ line is unknown. Here, we reveal that TAp73 …