A comparative site-directed mutagenesis study of staphylococcal enterotoxins A and B was
undertaken to identify key amino-acid residues which govern interactions with major …

Superantigens are thought to make external contacts with major histocompatibility complex
(MHC) class II molecules and with the V beta portion of a T cell antigen receptor (TCR) …

The staphylococcal enterotoxin A (SEA) is a superantigen that must bind to class II
molecules of the major histocompatibility complex to be recognized by T cells. In humans …

Staphylococcal enterotoxins are prototype superantigens characterized by their ability to
bind to major histocompatibility complex (MHC) class II molecules and subsequently activate …

The three-dimensional structure of staphylococcal enterotoxin B, which is both a toxin and a
super-antigen, has been determined to a resolution of 2.5 Å. The unusual main-chain fold …

Mutational studies indicate that the superantigen staphylococcal enterotoxin A (SEA) has
two separate binding sites for major histocompatibility complex (MHC) class II molecules …

Sir–The crystal structure of the superantigen staphylococcal enterotoxin B has recently been
published". On the basis of sequence homology and conserved amino-acid positions, a …

The superantigen staphylococcal enterotoxin A (SEA) binds to major histocompatibility
complex (MHC) class II molecules at two sites on either side of the peptide groove. Two …

Staphylococcal enterotoxins (SE) and toxic shock syndrome toxin 1 (TSST-1) bind to MHC
class II molecules and the toxin-class II complexes induce proliferation of T cells bearing …

Superantigens bind to MHC class II-positive cells and stimulate T lymphocytes expressing
specific V beta regions of the TCR. Two distinct regions of staphylococcal enterotoxin A …