[HTML][HTML] Amphipathic peptide antibiotics with potent activity against multidrug-resistant pathogens

J Shi, C Chen, D Wang, Z Tong, Z Wang, Y Liu - Pharmaceutics, 2021 - mdpi.com
The emergence and prevalence of multidrug-resistant (MDR) bacteria have posed a serious
threat to public health. Of particular concern are methicillin-resistant Staphylococcus aureus …

[HTML][HTML] Characterization of antimicrobial peptides toward the development of novel antibiotics

W Aoki, M Ueda - Pharmaceuticals, 2013 - mdpi.com
Antimicrobial agents have eradicated many infectious diseases and significantly improved
our living environment. However, abuse of antimicrobial agents has accelerated the …

De novo generation of short antimicrobial peptides with enhanced stability and cell specificity

H Kim, JH Jang, SC Kim, JH Cho - Journal of Antimicrobial …, 2014 - academic.oup.com
Abstract Objectives Though antimicrobial peptides (AMPs) show great potential as novel
antibiotics, therapeutic applications are hindered by their low stability, toxicity and high …

Antimicrobial peptides, an alternative antimicrobial agent against multi-drug-resistant microbes: Source, application, and potential

NHHL Ramzah, TW Yenn, WH Lee, CY Loo… - … in Materials Science …, 2023 - Springer
Pathogenic microorganisms are often associated with infectious diseases in humans, plants,
or animals. Over the past 100 years, antibiotics have been often used to combat the …

Host defense peptide mimicking peptide polymer exerting fast, broad spectrum, and potent activities toward clinically isolated multidrug-resistant bacteria

S Chen, X Shao, X Xiao, Y Dai, Y Wang… - ACS Infectious …, 2020 - ACS Publications
Multidrug-resistant (MDR) bacteria have emerged quickly and have caused serious
nosocomial infections. It is urgent to develop novel antimicrobial agents for treating MDR …

[HTML][HTML] Antimicrobial and antibiofilm activity of UP-5, an ultrashort antimicrobial peptide designed using only arginine and biphenylalanine

A Almaaytah, MT Qaoud, G Khalil Mohammed… - Pharmaceuticals, 2018 - mdpi.com
The recent upsurge of multidrug resistant bacteria (MDRB) among global communities has
become one of the most serious challenges facing health professionals and the human …

The design and functional characterization of the antimicrobial and antibiofilm activities of BMAP27-melittin, a rationally designed hybrid peptide

A Almaaytah, S Tarazi, M Al-Fandi, A Abuilhaija… - International Journal of …, 2015 - Springer
BMAP-27 and melittin are two antimicrobial peptides (AMPs) that display potent
antimicrobial activities against a wide range of microbes including multidrug resistant (MDR) …

New antimicrobial peptides with repeating unit against multidrug-resistant bacteria

C Zhong, F Zhang, J Yao, Y Zhu, N Zhu… - ACS Infectious …, 2021 - ACS Publications
With the aim of tackling the increasingly serious antimicrobial resistance and improving the
clinical potential of AMPs, a facile de novo strategy was adopted in this study, and a series of …

[HTML][HTML] The antimicrobial peptide LI14 combats multidrug-resistant bacterial infections

J Shi, C Chen, D Wang, Z Wang, Y Liu - Communications Biology, 2022 - nature.com
The prevalence of multidrug-resistant (MDR) pathogens raises public fears of untreatable
infections and represents a huge health risk. There is an urgent need to exploit novel …

[HTML][HTML] Hydrophilic/hydrophobic characters of antimicrobial peptides derived from animals and their effects on multidrug resistant clinical isolates

LIU Cun-Bao, S Bin, BAI Hong-Mei, T Jing… - Zoological …, 2015 - ncbi.nlm.nih.gov
Multidrug resistant (MDR) pathogen infections are serious threats to hospitalized patients
because of the limited therapeutic options. A novel group of antibiotic candidates …