Hybridization and antibiotic synergism as a tool for reducing the cytotoxicity of antimicrobial peptides

A Almaaytah, MT Qaoud, A Abualhaijaa… - Infection and drug …, 2018 - Taylor & Francis
Introduction: As the development of new antimicrobial agents faces a historical decline, the
issue of bacterial drug resistance has become a serious dilemma that threatens the human …

Antimicrobial peptides: a promising avenue for human healthcare

GM Bhopale - Current pharmaceutical biotechnology, 2020 - ingentaconnect.com
Antimicrobial drugs resistant microbes have been observed worldwide and therefore
alternative development of antimicrobial peptides has gained interest in human healthcare …

Synergistic activity profile of an antimicrobial peptide against multidrug‐resistant and extensively drug‐resistant strains of Gram‐negative bacterial pathogens

S Pollini, J Brunetti, S Sennati… - Journal of Peptide …, 2017 - Wiley Online Library
Infection sustained by multidrug‐resistant and extensively drug‐resistant bacterial
pathogens is often untreatable with the standard of care antibiotics, and the combination of …

[HTML][HTML] Chemical modifications to increase the therapeutic potential of antimicrobial peptides

Y Han, M Zhang, R Lai, Z Zhang - Peptides, 2021 - Elsevier
The continued use of antibiotics has been accompanied by the rapid emergence and spread
of antibiotic-resistant strains of bacteria. Antimicrobial peptides (AMPs), also known as host …

Discovery, optimization, and clinical application of natural antimicrobial peptides

AA Rodríguez, A Otero-González, M Ghattas… - Biomedicines, 2021 - mdpi.com
Antimicrobial peptides (AMPs) are widespread in multicellular organisms. These structurally
diverse molecules are produced as the first line of defense against pathogens such as …

Functional and toxicological evaluation of MAA-41: a novel rationally designed antimicrobial peptide using hybridization and modification methods from LL-37 and …

M Masadeh, A Ayyad, R Haddad… - Current …, 2022 - ingentaconnect.com
Background: Managing bacterial infections caused by multidrug-resistant (MDR) and
biofilmforming bacteria is a global health concern. Therefore, enormous efforts were directed …

Antimicrobial peptides–antibiotics combination: An effective strategy targeting drug‐resistant Gram‐negative bacteria

F Zhang, C Zhong, J Yao, J Zhang, T Zhang… - Peptide …, 2022 - Wiley Online Library
To address the growing resistance of Gram‐negative bacteria and enhance the clinical
application potential of antimicrobial peptides. In this study, we combined two α‐helical …

[HTML][HTML] Antibacterial activity of peptides and bio-safety evaluation: in vitro and in vivo studies against bacterial and fungal pathogens

MV Arasu, NA Al-Dhabi - Journal of Infection and Public Health, 2023 - Elsevier
Background Antimicrobial peptides are promising alternatives to antibiotics to treat bacterial
and fungal infections, especially drug-resistant clinical pathogens. Methods Antimicrobial …

A review of antimicrobial peptides: its function, mode of action and therapeutic potential

S Nayab, MA Aslam, S Rahman, ZD Sindhu… - International Journal of …, 2022 - Springer
Antimicrobial peptides (AMPs) are endogenous polypeptides produced by multicellular
organisms in order to protect a host from pathogenic microbes. AMPs are also defined as …

A short D-enantiomeric antimicrobial peptide with potent immunomodulatory and antibiofilm activity against multidrug-resistant Pseudomonas aeruginosa and …

MF Mohamed, A Brezden, H Mohammad… - Scientific Reports, 2017 - nature.com
Antimicrobial peptides (AMPs) represent a promising therapeutic alternative for the
treatment of antibiotic-resistant bacterial infections. The present study investigates the …