Antimicrobial peptides: potential alternative to antibiotics and overcoming limitations for future therapeutic applications

V Somase, SA Desai, VP Patel, V Patil… - International Journal of …, 2024 - Springer
Among all health-related issues, the rising concerns about drug resistance led to the look for
alternative pharmaceutical drugs that are effective against both infectious and noninfectious …

Antimicrobial peptides: the Achilles' heel of antibiotic resistance?

A Lewies, LH Du Plessis, JF Wentzel - Probiotics and antimicrobial …, 2019 - Springer
Antibiotic resistance is an imminent threat to the effective treatment of bacterial infections,
and alternative antibiotic strategies are urgently required. The golden epoch of antibiotics is …

A short D-enantiomeric antimicrobial peptide with potent immunomodulatory and antibiofilm activity against multidrug-resistant Pseudomonas aeruginosa and …

MF Mohamed, A Brezden, H Mohammad… - Scientific Reports, 2017 - nature.com
Antimicrobial peptides (AMPs) represent a promising therapeutic alternative for the
treatment of antibiotic-resistant bacterial infections. The present study investigates the …

Antibacterial activity of rationally designed antimicrobial peptides

MB Tincho, T Morris, M Meyer… - International Journal of …, 2020 - Wiley Online Library
Many infectious diseases are still prevalent in the world's populations since no effective
treatments are available to eradicate them. The reasons may either be the antibiotic …

[HTML][HTML] Antibacterial activity of peptides and bio-safety evaluation: in vitro and in vivo studies against bacterial and fungal pathogens

MV Arasu, NA Al-Dhabi - Journal of Infection and Public Health, 2023 - Elsevier
Background Antimicrobial peptides are promising alternatives to antibiotics to treat bacterial
and fungal infections, especially drug-resistant clinical pathogens. Methods Antimicrobial …

[HTML][HTML] Antimicrobial peptides for combating drug-resistant bacterial infections

J Xuan, W Feng, J Wang, R Wang, B Zhang, L Bo… - Drug Resistance …, 2023 - Elsevier
The problem of drug resistance due to long-term use of antibiotics has been a concern for
years. As this problem grows worse, infections caused by multiple bacteria are expanding …

DRAMP: a comprehensive data repository of antimicrobial peptides

L Fan, J Sun, M Zhou, J Zhou, X Lao, H Zheng, H Xu - Scientific reports, 2016 - nature.com
The growing problem of antibiotic-resistant microorganisms results in an urgent need for
substitutes to conventional antibiotics with novel modes of action and effective activities …

Antimicrobial peptides as effective agents against drug-resistant pathogens

P Tiwari, Y Srivastava, V Kumar - Antimicrobial Resistance: Underlying …, 2022 - Springer
The rising incidence of antimicrobial resistance continues to project a global healthcare
concern. The spread of drug-resistant pathogens and indiscriminate use of the existing …

Studies on the antibacterial activity and mechanism of antimicrobial peptides against drug-resistant bacteria

X Luo, Y Liu, Z Qin, Z Jin, L Xu, Y Liu… - Journal of …, 2018 - ingentaconnect.com
Antibiotic resistance is a growing threat to human health. More than anything else, multidrug-
resistant gram-negative bacteria pose the biggest challenge to healthcare, which is …

Designing the antimicrobial peptide with centrosymmetric and amphipathic characterizations for improving antimicrobial activity

PC Lee, CF Yen, CC Lin… - Journal of Peptide …, 2023 - Wiley Online Library
Antibiotic‐resistant bacterial infections are becoming a serious health issue and will cause
10 million deaths per year by 2050. As a result, the development of new antimicrobial agents …