Current state of a dual behaviour of antimicrobial peptides—Therapeutic agents and promising delivery vectors

U Piotrowska, M Sobczak… - Chemical Biology & Drug …, 2017 - Wiley Online Library
Micro‐organism resistance is an important challenge in modern medicine due to the global
uncontrolled use of antibiotics. Natural and synthetic antimicrobial peptides (AMP s) …

[HTML][HTML] Antimicrobial peptides as potential anti-biofilm agents against multidrug-resistant bacteria

PY Chung, R Khanum - Journal of microbiology, immunology and infection, 2017 - Elsevier
Bacterial resistance to commonly used drugs has become a global health problem, causing
increased infection cases and mortality rate. One of the main virulence determinants in many …

[HTML][HTML] New edge of antibiotic development: antimicrobial peptides and corresponding resistance

NS Parachin, OL Franco - Frontiers in microbiology, 2014 - frontiersin.org
In the last years severe efforts turned into extensive research on development of novel
antimicrobial compounds. Among them, antimicrobial peptides, commonly isolated from …

[HTML][HTML] Design, synthesis, and evaluation of amphiphilic cyclic and linear peptides composed of hydrophobic and positively-charged amino acids as antibacterial …

N Riahifard, S Mozaffari, T Aldakhil, F Nunez… - Molecules, 2018 - mdpi.com
Antimicrobial peptides (AMPs) contain amphipathic structures and are derived from natural
resources. AMPs have been found to be effective in treating the infections caused by …

Will new generations of modified antimicrobial peptides improve their potential as pharmaceuticals?

NK Brogden, KA Brogden - International journal of antimicrobial agents, 2011 - Elsevier
The concept of antimicrobial peptides (AMPs) as potent pharmaceuticals is firmly
established in the literature, and most research articles on this topic conclude by stating that …

[HTML][HTML] In vitro properties of designed antimicrobial peptides that exhibit potent antipneumococcal activity and produces synergism in combination with penicillin

CF Le, MYM Yusof, H Hassan, SD Sekaran - Scientific reports, 2015 - nature.com
Antimicrobial peptides (AMPs) represent a promising class of novel antimicrobial agents
owing to their potent antimicrobial activity. In this study, two lead peptides from unrelated …

Application of antimicrobial peptides as next-generation therapeutics in the biomedical world

M Datta, A Rajeev, I Chattopadhyay - Biotechnology and Genetic …, 2023 - Taylor & Francis
Antimicrobial peptide (AMP), also called host defense peptide, is a part of the innate immune
system in eukaryotic organisms. AMPs are also produced by prokaryotes in response to …

Antimicrobial peptides: a promising therapeutic strategy in tackling antimicrobial resistance

R Nuti, NS Goud, AP Saraswati… - Current medicinal …, 2017 - ingentaconnect.com
Background: Antimicrobial resistance (AMR) has posed a serious threat to global public
health and it requires immediate action, preferably long term. Current drug therapies have …

Antimicrobial peptides: therapeutic potentials

SJ Kang, SJ Park, T Mishig-Ochir… - Expert review of anti …, 2014 - Taylor & Francis
The increasing appearance of multidrug-resistant pathogens has created an urgent need for
suitable alternatives to current antibiotics. Antimicrobial peptides (AMPs), which act as …

[HTML][HTML] Synthetic antimicrobial peptides: Characteristics, design, and potential as alternative molecules to overcome microbial resistance

PG Lima, JTA Oliveira, JL Amaral, CDT Freitas… - Life Sciences, 2021 - Elsevier
Recently, the dramatic emergence of antimicrobial resistance has received attention from
World Health Organization. Synthetic antimicrobial peptides (SAMPs) are considered new …