Trained immunity: long-term adaptation in innate immune responses

H Tercan, NP Riksen, LAB Joosten… - … and Vascular Biology, 2021 - Am Heart Assoc
Adaptive immune responses are characterized by antigen specificity and induction of
lifelong immunologic memory. Recently, it has been reported that innate immune cells can …

Regulatory T cell memory

MD Rosenblum, SS Way, AK Abbas - Nature Reviews Immunology, 2016 - nature.com
Memory for antigen is a defining feature of adaptive immunity. Antigen-specific lymphocyte
populations show an increase in number and function after antigen encounter and more …

Memory-T-cell-derived interferon-γ instructs potent innate cell activation for protective immunity

SMH Soudja, C Chandrabos, E Yakob, M Veenstra… - Immunity, 2014 - cell.com
Cells of the innate immune system are essential for host defenses against primary microbial
pathogen infections, yet their involvement in effective memory responses of vaccinated …

Immunological memory to viral infections

RM Welsh, LK Selin… - Annu. Rev. Immunol., 2004 - annualreviews.org
▪ Abstract The purpose of immunological memory is to protect the host from reinfection, to
control persistent infections, and, through maternal antibody, to protect the host's …

Surviving the crash: transitioning from effector to memory CD8+ T cell

LM D'Cruz, MP Rubinstein, AW Goldrath - Seminars in immunology, 2009 - Elsevier
One outcome of infection is the formation of long-lived immunological memory, which
provides durable protection from symptomatic re-infection. In response to infection or …

The molecular basis of the memory T cell response: differential gene expression and its epigenetic regulation

N Weng, Y Araki, K Subedi - Nature Reviews Immunology, 2012 - nature.com
How the immune system remembers a previous encounter with a pathogen and responds
more efficiently to a subsequent encounter has been one of the central enigmas for …

[HTML][HTML] The role of cell metabolism in innate immune memory

AV Ferreira, J Domiguéz-Andrés… - Journal of Innate Immunity, 2022 - karger.com
Immunological memory is classically attributed to adaptive immune responses, but recent
studies have shown that challenged innate immune cells can display long-term functional …

Long-term reprogramming of the innate immune system

J Dominguez-Andres, MG Netea - Journal of leukocyte biology, 2019 - academic.oup.com
During the last few years, a growing body of evidence has shown that immunological
memory is not an exclusive trait of lymphocytes, as many inflammatory insults can alter the …

Innate immune memory: implications for host responses to damage‐associated molecular patterns

TO Crișan, MG Netea… - European journal of …, 2016 - Wiley Online Library
Cells of the innate immune system build immunological memory via epigenetic
reprogramming after stimulations with microbial ligands. This functional readjustment allows …

Potential role of gut microbiota in induction and regulation of innate immune memory

S Negi, DK Das, S Pahari, S Nadeem… - Frontiers in …, 2019 - frontiersin.org
The gut microbiota significantly regulates the development and function of the innate and
adaptive immune system. The attribute of immunological memory has long been linked only …