B-1 cells differ from conventional B-2 cells both phenotypically and functionally. Two
seemingly mutually exclusive hypotheses have been proposed to explain the origin of B-1 …

During their development, B and T cells with self-reactive antigen receptors are generally
deleted from the repertoire to avoid autoimmune diseases. Paradoxically, innate-like B-1 …

B-1 cells differ from conventional peripheral B cells (B-2) by anatomical location, surface
marker expression, antibody repertoire and growth properties. The lineage hypothesis of B-1 …

In contrast to the predominant population of B-2 B cells produced in the bone marrow, B-1 B
cells are a minor population of B lymphocytes that are found in multiple tissues, including the …

Since their discovery, B1 B cells' origins and developmental pathways have eluded
characterization. In the past year, focus on B1 B cells has shifted dramatically from …

Mouse B‐1 cells are not only major producers of steady‐state natural antibodies but also
rapid responders to infections and inflammation. These discrete functions may be the …

B-1 cells comprise a small percentage of the B lymphocytes that reside in multiple tissues in
the mouse, including the peritoneal and pleural cavities. Functionally, B-1 cells participate in …

B cell lineages: documented at last! | Nature Immunology Skip to main content Thank you for
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Diverse B cell responses are important for generating antibody‐mediated protection against
highly variable pathogens. While some antigens can trigger T‐independent B cell …

Highlights•Unique developmental paths generate self-reactive B-1 constraint in BCR
responses.•Extensive repertoire shaping of B-1 cells for months after birth.•Accumulating …