OBJECTIVES: To review recent advances in the understanding of molecular mechanisms of
drug disposition and cellular mechanisms of action and targets of colchicine, and disease …

Objectives To review the literature and provide an update on the mechanisms of action and
therapeutic uses of oral colchicine in arthritis and inflammatory conditions. Methods We …

Although colchicine has been a focus of research, debate, and controversy for thousands of
years, the US Food and Drug Administration just approved it in 2009. Over the past decade …

Purpose The aims of this article were to systematically review the literature about the
mechanism of action of colchicine in the multimodal pathology of acute inflammation …

Colchicine (COL) has been used in medicine for a long time. It is well recognized as a valid
therapy in acute flares of gouty arthritis, familial Mediterranean fever (FMF), Behçet's …

OBJECTIVE:: To present an update of the use of colchicine in patients with familial
Mediterranean fever (FMF) and other rheumatic and nonrheumatic diseases. DATA …

Objective Drug–drug interactions can limit the safety of colchicine for treating rheumatic
diseases. Seven separate drug–drug interaction (DDI) studies were performed to elucidate …

Although colchicine, a natural product, is one of the oldest drugs still currently available, its
possible functions seem to be surprisingly not well-known. Beyond its present medicinal use …

Colchicine is used chiefly in the treatment of gout but is also valuable in other inflammatory
diseases such as familial Mediterranean fever (FMF). Three proteins play pivotal roles in …

Colchicine is a unique anti-inflammatory drug with respect to its limited clinical usefulness
and its mode of action. Colchicine is mainly indicated for the treatment and prophylaxis of …