Aspergillus‐Associated Airway Disease, Inflammation, and the Innate Immune Response

SH Chotirmall, M Al-Alawi, B Mirkovic… - BioMed research …, 2013 - Wiley Online Library
Aspergillus moulds exist ubiquitously as spores that are inhaled in large numbers daily.
Whilst most are removed by anatomical barriers, disease may occur in certain …

Inflammatory cells and airway defense against Aspergillus fumigatus

HF Kauffman, JFC Tomee - Immunology and allergy clinics of North …, 1998 - Elsevier
Aspergillus fumigatus is known as a cause of multiple airway diseases that range from
harmless saprophytic colonization (presence of the fungus in sputum of healthy individuals) …

Aspergillus in chronic lung disease: Modeling what goes on in the airways

T Takazono, DC Sheppard - Sabouraudia, 2016 - academic.oup.com
Aspergillus species cause a range of respiratory diseases in humans. While
immunocompromised patients are at risk for the development of invasive infection with these …

The innate immune response to Aspergillus fumigatus at the alveolar surface

A Margalit, K Kavanagh - FEMS microbiology reviews, 2015 - academic.oup.com
Aspergillus fumigatus is an ubiquitous, saprophytic mould that forms and releases airborne
conidia which are inhaled by humans on a daily basis. When the immune system is …

The potential impact of the pulmonary microbiome on immunopathogenesis of Aspergillus‐related lung disease

E Kolwijck, FL van de Veerdonk - European Journal of …, 2014 - Wiley Online Library
Aspergillosis is an infection or allergic response caused by fungi of the genus Aspergillus.
The most common forms of aspergillosis are allergic bronchopulmonary aspergillosis …

[HTML][HTML] The innate immune response to Aspergillus fumigatus

V Balloy, M Chignard - Microbes and infection, 2009 - Elsevier
Despite the development of new treatments, the mortality due to invasive pulmonary
aspergillosis remains above 50%, reaching 95% in certain situations. The battle against …

Aspergillus‐related lung disease

A Al-Alawi, CF Ryan, JD Flint… - Canadian respiratory …, 2005 - Wiley Online Library
Aspergillus is a ubiquitous dimorphic fungus that causes a variety of human diseases
ranging in severity from trivial to life‐threatening, depending on the host response. An intact …

Innate Immunity to Aspergillus Species

SJ Park, B Mehrad - Clinical microbiology reviews, 2009 - Am Soc Microbiol
All humans are continuously exposed to inhaled Aspergillus conidia, yet healthy hosts clear
the organism without developing disease and without the development of antibody-or cell …

The emergence of Aspergillus species in chronic respiratory disease

ACA Yii, MS Koh, TS Lapperre, GL Tan, SH Chotirmall - 2017 - dr.ntu.edu.sg
Chronic lung disease is recognized as an important risk factor for developing pulmonary
aspergillosis. The development of specific aspergillus-associated syndromes depends on …

Aspergillus fumigatus

NS Wassano, GH Goldman, A Damasio - Trends in microbiology, 2020 - cell.com
Humans inhale hundreds of Aspergillus fumigatus conidia daily. Conidia germinate and
produce hyphae or mycelia that eventually form a colony. The recognition of A. fumigatus …