The objective of this hypothesis article is to review evidence supporting a role for calcium in
mediating ischemic brain damage, and to present data which puts mitochondrial dysfunction …

An account is given of calcium metabolism in the brain, with particular reference to the
possibility that loss of calcium homeostasis is the cause of ischemic neuronal necrosis. The …

Adult normothermic cats were submitted to 1-h complete cerebrocirculatory arrest, followed
by blood recirculation for 6–8 h. Two groups of animals could be distinguished: In one group …

Acute ischemic and brain injury is triggered by excitotoxic elevation of intraneuronal Ca2+
followed by reoxygenation-dependent oxidative stress, metabolic failure, and cell death …

It is widely accepted that disturbances of calcium homeostasis play a key role in the
development of cell damage produced by transient cerebral ischemia. It is believed that the …

Hypoxia and ischemia produce depression of myocardial contractile function and alterations
in calcium homeostasis. Although both functional abnormalities and alterations in calcium …

Publisher Summary This chapter describes the pathways that are responsible for
mitochondrial calcium transport and discusses these pathways that act in concert to limit the …

Calcium was localized in neurons and glial cells of the CA 1 region of hippocampus and in
neurons of parietal cortex with the oxalate-pyroantimonate electron cytochemical method …

Tissues subjected to chemical poisoning or ischaemia followed by reperfusion experience
oxidative stress as a result of both an increase in oxygen free radical species and a …

It is widely believed that calcium plays a primary role in the development of neuronal cell
injury in different pathological states of the brain. Disturbances of calcium homeostasis may …