Atherosclerosis is the major cause of cardiovascular disease (CVD). Monocyte-derived
macrophages are the most abundant immune cells in atherosclerotic plaques. In patients …

Atherosclerosis is a chronic inflammatory disease driven by lipids and other atherogenic
factors. It is characterized by a dynamic and complex pathological process of bone marrow …

BACKGROUND: Aging represents the most powerful risk for the development of
atherosclerosis and atherosclerotic thromboembolic complications. Yet, the mechanism by …

Aims Experimental work posits that acute ischaemic events trigger haematopoietic activity,
driving monocytosis, and atherogenesis. Considering the chronic low-grade inflammatory …

Circulating bone marrow (BM)-derived stem and progenitor cells (SPCs) participate in
turnover of vascular endothelium and myocardial repair after acute coronary syndromes …

Introduction Although autologous bone marrow cell (BMC) therapy has emerged as a
promising treatment for acute myocardial infarction (AMI), trials reported mixed results. In the …

A central feature of atherosclerosis, the most prevalent chronic vascular disease and root
cause of myocardial infarction and stroke, is leukocyte accumulation in the arterial wall …

A large number of cardiovascular events are not prevented by current therapeutic regimens.
In search for additional, innovative strategies, immune cells have been recognized as key …

Bone marrow-derived cells which may be involved in cardiac repair/regeneration after
ischaemic injury must undergo mobilisation into peripheral blood with subsequent homing …

Modulation of hematopoietic stem and progenitor cells (HSPCs) determines immune cell
function. In this study, we investigated how hypercholesterolemia affects HSPC biology and …