DNA methylation occurs on cytosines, is catalyzed by DNA methyltransferases (DNMTs),
and is present at high levels in all vertebrates. DNA methylation plays essential roles in …

Methylation of DNA is an essential epigenetic control mechanism in mammals. During
embryonic development, cells are directed toward their future lineages, and DNA …

DNA methylation in mammals is a key epigenetic modification essential to normal genome
regulation and development. DNA methylation patterns are established during early …

DNA methylation (5-methylcytosine, 5mC) is a major form of DNA modification in the
mammalian genome that plays critical roles in chromatin structure and gene expression. In …

DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

DNA methylation is a major epigenetic regulatory mechanism for gene expression and cell
differentiation. Until recently, it was still unclear how unmethylated regions in mammalian …

Mammalian development is associated with considerable changes in global DNA
methylation levels at times of genomic reprogramming. Normal DNA methylation is essential …

DNA methylation is dynamically remodelled during the mammalian life cycle through distinct
phases of reprogramming and de novo methylation. These events enable the acquisition of …

DNA methylation is an epigenetic mark associated with transcriptional repression and
essential for proper vertebrate development. Because of its association with human …

DNA methylation is an essential epigenetic modification for mammalian development and is
crucial for the establishment and maintenance of cellular identity. Traditionally, DNA …