Histone modifying enzymes catalyze the addition or removal of an array of covalent
modifications in histone and non-histone proteins. Within the context of chromatin, these …

Histone modifications are thought to regulate chromatin structure, transcription and other
nuclear processes. Histone methylation was originally believed to be an irreversible …

The nucleosome is the fundamental unit of chromatin. It is composed of an octamer of the
four core histones (H3, H4, H2A, H2B) around which 147 base pairs of DNA are wrapped …

Histones are highly conserved small basic proteins that are found exclusively in eukaryotic
cells, predominantly in the nucleus. First described in 1884 by Albrecht Kossel, using an …

The importance of histone methylation in gene regulation was suggested over 40 years ago.
Yet, the dynamic nature of this histone modification was recognized only recently, with the …

In 1964, Alfrey and colleagues proposed that acetylation and methylation of histones may
regulate RNA synthesis and described “the possibility that relatively minor modifications of …

Histones form the protein core around which genomic DNA is wrapped in eukaryotic
chromatin. Numerous genetic studies have established that the structure and transcriptional …

Histones are abundant nuclear proteins that are essential for the packaging of eukaryotic
DNA into chromosomes. Different histone variants, in combination with their modification …

Mutations in the molecular pathways that regulate cell proliferation, differentiation, and cell
death all contribute to cancer formation. Enzymes that covalently modify histones affect …

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