The crystal structure of interferon-γ bound to the extracellular fragment of its high-affinity
cellsurface receptor reveals the first view of a class-2 cytokine receptor-ligand complex. In …

Abstract Interleukin-1 (IL-1) is an important mediator of inflammatory disease. The IL-1 family
currently consists of two agonists, IL-1α and IL-lβ, and one antagonist, IL-1ra. Each of these …

Previous research suggests that interferon binds to the cell surface1, possibly by attachment
to gangliosides2, 3. A two-component receptor system consisting of binding and activation …

The high affinity receptor for interleukin‐2 (IL‐2) contains three subunits called IL‐2R alpha,
beta and gamma. A biological and receptor binding analysis based on 1393 different mutant …

We determined the species specificity and function of structural domains of the interferon-
gamma receptor (IFN-gamma R) by construction of human/murine chimeric IFN-gamma R …

The extracellular domain (ECD) of the human interferon-gamma (IFN gamma) receptor was
stably expressed in Chinese hamster ovary cells and purified to homogeneity. Scatchard …

The type-1 insulin-like growth-factor receptor (IGF-1R) and insulin receptor (IR) are closely
related members of the tyrosine-kinase receptor superfamily. IR is essential for glucose …

THE interaction of interleukin-2 (IL-2) and IL-2 receptors criti-cally regulates the T-cell
immune response following antigen activation1, 2. IL-2 can signal through high or …

Abstract INTERLEUKIN-5 (IL-5) is a lineage-specific cytokine for eosinophilpoiesis and
plays an important part in diseases associ-ated with increased eosinophils, such as …

Inflammation, regardless of whether it is provoked by infection or by tissue damage, starts
with the activation of macrophages which initiate a cascade of inflammatory responses by …