Encouraged by recent findings showing the usefulness of nonreplicating antigen delivery
systems in the induction of mucosal immune responses, we investigated microspheres as a …

Poly-(lactide-co-glycolide) microspheres with entrapped antigen have shown considerable
promise as controlled release vaccines. To enhance the immunomodulatory effect of LW …

Biodegradable and biocompatible microspheres have been investigated for their usefulness
as a vaccine delivery system for both parenteral and enteral immunization. Microspheres …

Mucosal administration of antigen is known to be appropriate for vaccine purposes as well
as tolerance induction. Biodegradable poly (dl-lactide-co-glycolide)(PLGA) microparticles …

Oral administration of antigens has long been recognized as a method to prevent or delay
the onset of diseases associated with untoward immune responses to self and non-self …

Background Biodegradable microparticles, in particular poly (lactide‐co‐glycolide)(PLGA),
have been shown as potential delivery vehicles for intranasal (in) vaccines in animal …

Microspheres prepared from various polymers were evaluated for their usefulness as
carriers for the targeted delivery of vaccine antigens to the gut-associated lymphoid tissues …

Previous studies demonstrated in vitro phagocytosis of poly (lactide-co-glycolide)(PLGA)
microspheres (MS) by macrophages and dendritic cells and the biodistribution of fluorescent …

We have examined the range of mucosal and systemic immune responses induced by oral
or parenteral immunization with ovalbumin (OVA) entrapped in poly (D, L-lactide-co …

Herein we describe a formulation of self-encapsulating poly (lactic-co-glycolic acid)(PLGA)
microspheres for vaccine delivery. Self-healing encapsulation is a novel encapsulation …