Abstract β-Catenin functions as a transducer of Wnt signals to the nucleus, where it interacts
with the T cell factor (TCF) family of DNA binding proteins to regulate gene expression. On …

Wnts compose a family of signaling proteins that play an essential role in kidney
development, but their expression in adult kidney is thought to be silenced. Here, we …

Wnt/β‐catenin is an evolutionarily conserved, developmental signalling pathway that
regulates embryogenesis, injury repair and pathogenesis of human diseases. Dysregulated …

Wnt/β-catenin signaling is an evolutionarily conserved, highly complex, key developmental
pathway that regulates cell fate, organ development, tissue homeostasis, as well as injury …

Wnt-4 is a secreted glycoprotein that is critical for genitourinary development but found only
in the most distal collecting duct epithelium in the normal murine adult kidney. Wnt4 …

The Wnt signaling pathway is central to the development of all animals and to cancer
progression, yet largely unknown are the pairings of secreted Wnt ligands to their respective …

Fibrosis of epithelial parenchymal organs and end-stage organ failure, the final common
pathway of many progressive chronic diseases including chronic kidney disease, continue …

Wnt signal cascade is an evolutionarily conserved, developmental pathway that regulates
embryogenesis, injury repair, and pathogenesis of human diseases. It is well established …

Wnt-4 signaling plays a critical role in kidney development and is associated with the
epithelial conversion of the metanephric mesenchyme. Furthermore, secreted Frizzled …

Cell-cell communication via Wnt ligands is necessary in regulating embryonic development
and has been implicated in CKD. Because Wnt ligands are ubiquitously expressed, the …