[HTML][HTML] Mechanoreceptor signal convergence and transformation in the dorsal horn flexibly shape a diversity of outputs to the brain

AM Chirila, G Rankin, SY Tseng, AJ Emanuel… - Cell, 2022 - cell.com
The encoding of touch in the spinal cord dorsal horn (DH) and its influence on tactile
representations in the brain are poorly understood. Using a range of mechanical stimuli …

[HTML][HTML] The sensory neurons of touch

VE Abraira, DD Ginty - neuron, 2013 - cell.com
The somatosensory system decodes a wide range of tactile stimuli and thus endows us with
a remarkable capacity for object recognition, texture discrimination, sensory-motor feedback …

[HTML][HTML] Mechanoreceptor synapses in the brainstem shape the central representation of touch

BP Lehnert, C Santiago, EL Huey, AJ Emanuel… - Cell, 2021 - cell.com
Mammals use glabrous (hairless) skin of their hands and feet to navigate and manipulate
their environment. Cortical maps of the body surface across species contain …

The mechanosensory neurons of touch and their mechanisms of activation

A Handler, DD Ginty - Nature Reviews Neuroscience, 2021 - nature.com
Our sense of touch emerges from an array of mechanosensory structures residing within the
fabric of our skin. These tactile end organ structures convert innocuous forces acting on the …

Excitatory and inhibitory neurons of the spinal cord superficial dorsal horn diverge in their somatosensory responses and plasticity in vivo

SJ Sullivan, AD Sdrulla - Journal of Neuroscience, 2022 - Soc Neuroscience
The superficial dorsal horn (SDH) of the spinal cord represents the first site of integration
between innocuous and noxious somatosensory stimuli. According to gate control theory …

[HTML][HTML] The encoding of touch by somatotopically aligned dorsal column subdivisions

J Turecek, BP Lehnert, DD Ginty - Nature, 2022 - nature.com
The somatosensory system decodes a range of tactile stimuli to generate a coherent sense
of touch. Discriminative touch of the body depends on signals conveyed from peripheral …

[HTML][HTML] Identification of spinal neurons contributing to the dorsal column projection mediating fine touch and corrective motor movements

S Paixão, L Loschek, L Gaitanos, PA Morales… - Neuron, 2019 - cell.com
Tactile stimuli are integrated and processed by neuronal circuits in the deep dorsal horn of
the spinal cord. Several spinal interneuron populations have been implicated in tactile …

[HTML][HTML] Neural basis of touch and proprioception in primate cortex

BP Delhaye, KH Long, SJ Bensmaia - Comprehensive Physiology, 2018 - ncbi.nlm.nih.gov
The sense of proprioception allows us to keep track of our limb posture and movements and
the sense of touch provides us with information about objects with which we come into …

Tissue mechanics govern the rapidly adapting and symmetrical response to touch

AL Eastwood, A Sanzeni, BC Petzold… - Proceedings of the …, 2015 - National Acad Sciences
Interactions with the physical world are deeply rooted in our sense of touch and depend on
ensembles of somatosensory neurons that invade and innervate the skin. Somatosensory …

[HTML][HTML] The cellular and synaptic architecture of the mechanosensory dorsal horn

VE Abraira, ED Kuehn, AM Chirila, MW Springel… - Cell, 2017 - cell.com
The deep dorsal horn is a poorly characterized spinal cord region implicated in processing
low-threshold mechanoreceptor (LTMR) information. We report an array of mouse genetic …