Several lines of evidence strongly implicate type I interferons (IFN-α and β) and IFN-
signaling in the pathogenesis of certain autoimmune inflammatory diseases. Accordingly …

Type I interferons (IFN) can have dual and opposing roles in immunity, with effects that are
beneficial or detrimental to the individual depending on whether IFN pathway activation is …

Interferon α or β: which is the culprit in autoimmune disease? | Nature Reviews Rheumatology
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In conjunction with the development of genome-wide technology, numerous studies have
revealed the importance of regulatory mechanisms to avoid the onset of autoimmunity. In …

Type I interferons (IFNs) play essential roles in establishing and modulating host defense
against microbial infection via induction of IFN-stimulated genes (ISGs) through Janus …

Type I interferon (IFN-I) is thought to play a role in many systemic autoimmune diseases. IFN-
I pathway activation is associated with pathogenic features, including the presence of …

Abstract Type I interferons (IFN-Is) are a very important group of cytokines that are produced
by innate immune cells but also act on adaptive immune cells. IFN-Is possess antiviral …

Abstract Type-I interferon (IFN)-mediated immune response involves both innate and
adaptive immune system and has a pivotal role in antiviral defence. A complex interplay of …

Type I interferons (IFN-I) and their cognate receptor, the IFNAR1/2 heterodimer, are critical
components of the innate immune system in humans. They have been widely explored in …

Abstract Purpose of Review Type I interferons (IFNαβ) induce the expression of hundreds of
genes; thus, it is unsurprising that the initiation, transmission, and resolution of the IFNαβ …