The past 20 years have seen the definition of human monogenic disorders and their
autoimmune phenocopies underlying either defective or enhanced type I interferon (IFN) …

Interferon regulatory factors (IRFs) were first identified during studies of type I interferons.
Since then, many investigations have established that IRFs are involved in regulating the …

Type I interferons (IFNs) have recently received a lot of attention with the elucidation of the
pathogenesis of systemic lupus erythematosus (SLE). Type I IFNs are associated with many …

The first description of the involvement of interferons (IFN) in systemic autoimmune diseases
(AID) dates back more than 40 years. 1 IFNs play a crucial role in numbers of immunological …

Interleukin-1β (IL-1β) and type I interferons (IFNs) are major cytokines involved in
autoinflammatory/autoimmune diseases. Separately, the overproduction of each of these …

The type I interferon pathway has been implicated in the pathogenesis of a number of
rheumatic diseases, including systemic lupus erythematosus, Sjögren syndrome, myositis …

The interferon signature in autoimmune diseases : Current Opinion in Rheumatology The
interferon signature in autoimmune diseases : Current Opinion in Rheumatology Log in or …

A significant role for IFNα in the pathogenesis of systemic lupus erythematosus is well
supported, and clinical trials of anti-IFNα monoclonal antibodies are in progress in this …

Type I interferon is a potent substance. As such, the induction, transmission, and resolution
of the type I interferon–mediated immune response are tightly regulated. As defined, the type …

Type I and III interferons (IFNs) activate similar downstream signaling cascades, but unlike
type I IFNs, type III IFNs (IFNλ) do not elicit strong inflammatory responses in vivo. Here, we …