Type I interferons (IFNs) are critical effector cytokines of the immune system and were
originally known for their important role in protecting against viral infections; however, they …

Interferons are pleiotropic cytokines with important proinflammatory functions required in
defence against infections with bacteria, viruses and multicellular parasites. In recent years …

Objective Peripheral blood mononuclear cells (PBMCs) in systemic lupus erythematosus
(SLE) patients exhibit a gene expression program (interferon [IFN] signature) that is …

Abstract Purpose of the Review Type I interferonopathies are monogenic autoinflammatory
diseases induced by constitutive activation of type I interferon. Here, we provide an overview …

Cytokines are pleiotropic molecules showing a wide variety of biological functions on
various cells and tissues. Several different cytokines exert similar and overlapping functions …

In recent years, the study of systemic lupus erythematosus (SLE) patients has revealed a
central role for type I interferon (IFN) in disease pathogenesis. IFN induces the unabated …

There is increasing scientific and clinical interest in elucidating the biology of type I
Interferons, which began approximately 60 years ago with the concept of “viral interference” …

Background: Since their initial use in the 1980s, IFNs have become an essential component
of the therapy for many diseases such as hepatitis and multiple sclerosis. Although they …

It is now well accepted that interferon (IFN) alpha plays a critical role in the pathogenesis
and perpetuation of specific autoimmune diseases, including systemic lupus erythematosus …

Dysregulation of type I interferons (IFNs) has been implicated in the pathogenesis of
systemic lupus erythematosus (SLE) since the late 1970s. The majority of SLE patients …