Quercetin ameliorates insulin resistance and restores gut microbiome in mice on high-fat diets

Y Tan, CC Tam, M Rolston, P Alves, L Chen, S Meng… - Antioxidants, 2021 - mdpi.com
Quercetin is a flavonoid that has been shown to have health-promoting capacities due to its
potent antioxidant activity. However, the effect of chronic intake of quercetin on the gut …

Quercetin improves high‐fat diet‐induced obesity by modulating gut microbiota and metabolites in C57BL/6J mice

L Su, Y Zeng, G Li, J Chen, X Chen - Phytotherapy Research, 2022 - Wiley Online Library
High‐fat diet‐induced obesity is characterized by low‐grade inflammation, which has been
linked to gut microbiota dysbiosis. We hypothesized that quercetin supplementation would …

A combination of quercetin and resveratrol reduces obesity in high-fat diet-fed rats by modulation of gut microbiota

L Zhao, Q Zhang, W Ma, F Tian, H Shen, M Zhou - Food & function, 2017 - pubs.rsc.org
Resveratrol and quercetin, widely found in foods and vegetables, are plant polyphenols
reported to have a wide range of biological activities. Despite their limited bioavailabilities …

The roles of quercetin in diabetes mellitus and related metabolic disorders; special focus on the modulation of gut microbiota: A comprehensive review

N Roshanravan, SF Askari, S Fazelian… - Critical Reviews in …, 2023 - Taylor & Francis
Quercetin is a dietary flavonoid that can affect the balance between anti-oxidant defense
system and oxidative stress. A number of studies showed the positive effects of quercetin on …

Transcriptomic and metabonomic profiling reveal synergistic effects of quercetin and resveratrol supplementation in high fat diet fed mice

M Zhou, S Wang, A Zhao, K Wang, Z Fan… - Journal of proteome …, 2012 - ACS Publications
Dietary quercetin and resveratrol have been frequently used in treating various diseases,
but the underlying mechanisms are not entirely clear. Here, we report combined …

Isoquercetin and inulin synergistically modulate the gut microbiome to prevent development of the metabolic syndrome in mice fed a high fat diet

S Tan, JA Caparros-Martin, VB Matthews, H Koch… - Scientific Reports, 2018 - nature.com
Dietary fibre positively influences gut microbiome composition, enhancing the metabolism of
dietary flavonoids to produce bioactive metabolites. These synergistic activities facilitate the …

[HTML][HTML] Quercetin ameliorates hyperglycemia and dyslipidemia and improves antioxidant status in type 2 diabetic db/db mice

SM Jeong, MJ Kang, HN Choi, JH Kim… - Nutrition research and …, 2012 - ncbi.nlm.nih.gov
This study investigated the hypoglycemic, hypolipidemic, and antioxidant effects of dietary
quercetin in an animal model of type 2 diabetes mellitus. Four-week-old C57BL/KsJ-db/db …

Quercetin suppresses immune cell accumulation and improves mitochondrial gene expression in adipose tissue of diet‐induced obese mice

M Kobori, Y Takahashi, M Sakurai… - Molecular nutrition & …, 2016 - Wiley Online Library
Scope To examine the effect of dietary quercetin on the function of epididymal adipose
tissue (EAT) in Western diet‐induced obese mice. Methods and results C57BL/6J mice were …

Enhanced alleviation of insulin resistance via the IRS-1/Akt/FOXO1 pathway by combining quercetin and EGCG and involving miR-27a-3p and miR-96–5p

H Liu, H Guan, X Tan, Y Jiang, F Li… - Free radical biology and …, 2022 - Elsevier
Quercetin and EGCG exhibit anti-diabetic and anti-obesity activities, however, their
interactive effects in anti-diabetic/anti-obesity actions and underlying mechanisms remain …

Modulation of chronic inflammation by quercetin: The beneficial effects on obesity

S Sato, Y Mukai - Journal of inflammation research, 2020 - Taylor & Francis
Obesity has become a major risk factor for the development of chronic diseases such as
insulin resistance, type 2 diabetes mellitus, and cardiovascular disease. Moreover, obesity …