Analysis of the mechanism of action of quercetin in the treatment of hyperlipidemia based on metabolomics and intestinal flora

T Wang, L Liu, J Deng, Y Jiang, X Yan, W Liu - Food & function, 2023 - pubs.rsc.org
Hyperlipidemia (HLP) is one of the main factors leading to cardiovascular diseases.
Quercetin (QUE) is a naturally occurring polyhydroxy flavonoid compound that has a wide …

[HTML][HTML] Quercetin lowers plasma triglycerides accompanied by white adipose tissue browning in diet-induced obese mice

EN Kuipers, AD Dam, NM Held, IM Mol… - International journal of …, 2018 - mdpi.com
Obesity and dyslipidemia are major risk factors for the development of cardiovascular
diseases (CVD). Quercetin, a natural flavonoid, lowers plasma triglycerides (TG) in human …

[HTML][HTML] Quercetin impacts expression of metabolism-and obesity-associated genes in SGBS adipocytes

A Leiherer, K Stoemmer, A Muendlein, CH Saely… - Nutrients, 2016 - mdpi.com
Obesity is characterized by the rapid expansion of visceral adipose tissue, resulting in a
hypoxic environment in adipose tissue which leads to a profound change of gene …

[HTML][HTML] Quercetin positively affects gene expression profiles and metabolic pathway of antibiotic-treated mouse gut microbiota

W Mi, Z Hu, L Xu, X Bian, W Lian, S Yin… - Frontiers in …, 2022 - frontiersin.org
Quercetin has a wide range of biological properties that can be used to prevent or decrease
particular inflammatory diseases. In this study, we aimed to investigate the gene expression …

[HTML][HTML] Quercetin and green tea extract supplementation downregulates genes related to tissue inflammatory responses to a 12-week high fat-diet in mice

L Cialdella-Kam, S Ghosh, MP Meaney, AM Knab… - Nutrients, 2017 - mdpi.com
Quercetin (Q) and green tea extract (E) are reported to counter insulin resistance and
inflammation and favorably alter fat metabolism. We investigated whether a mixture of E+ Q …

[HTML][HTML] Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: A mechanism including AMPKα1/SIRT1 [S]

J Dong, X Zhang, L Zhang, HX Bian, N Xu, B Bao… - Journal of lipid …, 2014 - ASBMB
Adipose tissue macrophage (ATM) plays a central role in obesity-associated inflammation
and insulin resistance. Quercetin, a dietary flavonoid, possesses anti-inflammation and anti …

Dietary quercetin alleviates diabetic symptoms and reduces streptozotocin‐induced disturbance of hepatic gene expression in mice

M Kobori, S Masumoto, Y Akimoto… - Molecular nutrition & …, 2009 - Wiley Online Library
Quercetin is a food component that may ameliorate the diabetic symptoms. We examined
hepatic gene expression of BALB/c mice with streptozotocin (STZ)‐induced diabetes to …

Improvement of intestinal barrier function, gut microbiota, and metabolic endotoxemia in type 2 diabetes rats by curcumin

J Huang, B Guan, L Lin, Y Wang - Bioengineered, 2021 - Taylor & Francis
Type 2 diabetes mellitus (T2DM) is known as a complex genetic disease characterized by
genetic and environmental factors. The imbalanced intestinal flora and intestinal mucosal …

[HTML][HTML] Failure of dietary quercetin to alter the temporal progression of insulin resistance among tissues of C57BL/6J mice during the development of diet-induced …

LK Stewart, Z Wang, D Ribnicky, JL Soileau, WT Cefalu… - Diabetologia, 2009 - Springer
Aims/hypotheses High-fat diets produce obesity and glucose intolerance by promoting the
development of insulin resistance in peripheral tissues and liver. The present studies sought …

[HTML][HTML] Curcumin improves insulin sensitivity in high-fat diet-fed mice through gut microbiota

Y Zhong, Y Xiao, J Gao, Z Zheng, Z Zhang, L Yao… - Nutrition & …, 2022 - Springer
Background Insulin resistance precedes metabolic syndrome which increases the risk of
type 2 diabetes and cardiovascular disease. However, there is a lack of safe and long …