Emerging opportunities to treat idiopathic pulmonary fibrosis: Design, discovery, and optimizations of small-molecule drugs targeting fibrogenic pathways
Idiopathic pulmonary fibrosis (IPF) is the most common fibrotic form of idiopathic diffuse lung
disease. Due to limited treatment options, IPF patients suffer from poor survival. About ten …
disease. Due to limited treatment options, IPF patients suffer from poor survival. About ten …
Exploitation of novel molecular targets to treat idiopathic pulmonary fibrosis: a drug discovery perspective
Background: Idiopathic pulmonary fibrosis (IPF) is the most common fibrosing lung disease
and is caused by excessive lung scarring. IPF-associated severe mortality can be attributed …
and is caused by excessive lung scarring. IPF-associated severe mortality can be attributed …
Current advances in idiopathic pulmonary fibrosis: the pathogenesis, therapeutic strategies and candidate molecules
M Lv, Y Liu, S Ma, Z Yu - Future medicinal chemistry, 2019 - Taylor & Francis
Idiopathic pulmonary fibrosis (IPF) is a type of chronic, progressive lung disease with
unknown cause, which is characterized by increasing dyspnea and destruction of lung …
unknown cause, which is characterized by increasing dyspnea and destruction of lung …
Novel drug targets for idiopathic pulmonary fibrosis
G Sgalla, E Cocconcelli, R Tonelli… - Expert review of …, 2016 - Taylor & Francis
ABSTRACT Idiopathic Pulmonary Fibrosis (IPF) is a progressive, fatal lung disorder of
unknown cause with a highly variable and unpredictable clinical course. The advances …
unknown cause with a highly variable and unpredictable clinical course. The advances …
New therapeutics based on emerging concepts in pulmonary fibrosis
Introduction: Fibrosis is an irreversible pathological endpoint in many chronic diseases,
including pulmonary fibrosis. Idiopathic pulmonary fibrosis (IPF) is a progressive and often …
including pulmonary fibrosis. Idiopathic pulmonary fibrosis (IPF) is a progressive and often …
Shedding light on developmental drugs for idiopathic pulmonary fibrosis
P Spagnolo, F Bonella, CJ Ryerson… - Expert Opinion on …, 2020 - Taylor & Francis
Introduction Idiopathic pulmonary fibrosis (IPF) is an age-related disease of unknown cause.
The disease is characterized by relentless scarring of the lung parenchyma resulting in …
The disease is characterized by relentless scarring of the lung parenchyma resulting in …
Progress in understanding and treating idiopathic pulmonary fibrosis: Recent insights and emerging therapies
H Guo, J Sun, S Zhang, Y Nie, S Zhou… - Frontiers in …, 2023 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a long-lasting, continuously advancing, and irrevocable
interstitial lung disorder with an obscure origin and inadequately comprehended …
interstitial lung disorder with an obscure origin and inadequately comprehended …
Idiopathic pulmonary fibrosis: current status, recent progress, and emerging targets
YM Liu, K Nepali, JP Liou - Journal of medicinal chemistry, 2017 - ACS Publications
Idiopathic pulmonary fibrosis (IPF), a chronic and progressive fibrosing interstitial
pneumonia, is a fatal lung disease with a median survival time of 3–5 years. Problems in …
pneumonia, is a fatal lung disease with a median survival time of 3–5 years. Problems in …
An update on emerging drugs for the treatment of idiopathic pulmonary fibrosis: a look towards 2023 and beyond
C Sofia, A Comes, G Sgalla… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Currently approved drug treatments for idiopathic pulmonary fibrosis (IPF),
pirfenidone and nintedanib, have been shown to slow lung function decline and improve …
pirfenidone and nintedanib, have been shown to slow lung function decline and improve …
Research progress in the molecular mechanisms, therapeutic targets, and drug development of idiopathic pulmonary fibrosis
H Ma, X Wu, Y Li, Y Xia - Frontiers in Pharmacology, 2022 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease. Recent studies have
identified the key role of crosstalk between dysregulated epithelial cells, mesenchymal …
identified the key role of crosstalk between dysregulated epithelial cells, mesenchymal …