Emerging opportunities to treat idiopathic pulmonary fibrosis: Design, discovery, and optimizations of small-molecule drugs targeting fibrogenic pathways

W Luo, Y Gu, S Fu, J Wang, J Zhang, Y Wang - European Journal of …, 2023 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is the most common fibrotic form of idiopathic diffuse lung
disease. Due to limited treatment options, IPF patients suffer from poor survival. About ten …

Exploitation of novel molecular targets to treat idiopathic pulmonary fibrosis: a drug discovery perspective

B Vaidya, R Patel, A Muth… - Current Medicinal …, 2017 - ingentaconnect.com
Background: Idiopathic pulmonary fibrosis (IPF) is the most common fibrosing lung disease
and is caused by excessive lung scarring. IPF-associated severe mortality can be attributed …

Current advances in idiopathic pulmonary fibrosis: the pathogenesis, therapeutic strategies and candidate molecules

M Lv, Y Liu, S Ma, Z Yu - Future medicinal chemistry, 2019 - Taylor & Francis
Idiopathic pulmonary fibrosis (IPF) is a type of chronic, progressive lung disease with
unknown cause, which is characterized by increasing dyspnea and destruction of lung …

Novel drug targets for idiopathic pulmonary fibrosis

G Sgalla, E Cocconcelli, R Tonelli… - Expert review of …, 2016 - Taylor & Francis
ABSTRACT Idiopathic Pulmonary Fibrosis (IPF) is a progressive, fatal lung disorder of
unknown cause with a highly variable and unpredictable clinical course. The advances …

New therapeutics based on emerging concepts in pulmonary fibrosis

V Sontake, PR Gajjala, RK Kasam… - Expert opinion on …, 2019 - Taylor & Francis
Introduction: Fibrosis is an irreversible pathological endpoint in many chronic diseases,
including pulmonary fibrosis. Idiopathic pulmonary fibrosis (IPF) is a progressive and often …

Shedding light on developmental drugs for idiopathic pulmonary fibrosis

P Spagnolo, F Bonella, CJ Ryerson… - Expert Opinion on …, 2020 - Taylor & Francis
Introduction Idiopathic pulmonary fibrosis (IPF) is an age-related disease of unknown cause.
The disease is characterized by relentless scarring of the lung parenchyma resulting in …

Progress in understanding and treating idiopathic pulmonary fibrosis: Recent insights and emerging therapies

H Guo, J Sun, S Zhang, Y Nie, S Zhou… - Frontiers in …, 2023 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a long-lasting, continuously advancing, and irrevocable
interstitial lung disorder with an obscure origin and inadequately comprehended …

Idiopathic pulmonary fibrosis: current status, recent progress, and emerging targets

YM Liu, K Nepali, JP Liou - Journal of medicinal chemistry, 2017 - ACS Publications
Idiopathic pulmonary fibrosis (IPF), a chronic and progressive fibrosing interstitial
pneumonia, is a fatal lung disease with a median survival time of 3–5 years. Problems in …

An update on emerging drugs for the treatment of idiopathic pulmonary fibrosis: a look towards 2023 and beyond

C Sofia, A Comes, G Sgalla… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Currently approved drug treatments for idiopathic pulmonary fibrosis (IPF),
pirfenidone and nintedanib, have been shown to slow lung function decline and improve …

Research progress in the molecular mechanisms, therapeutic targets, and drug development of idiopathic pulmonary fibrosis

H Ma, X Wu, Y Li, Y Xia - Frontiers in Pharmacology, 2022 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease. Recent studies have
identified the key role of crosstalk between dysregulated epithelial cells, mesenchymal …